Now showing items 4961-4970 of 5058
Development and Application of Metabolomic Techniques for Identification and Quantification of Intercellular Metabolites Relevant to Glucose Stimulated Insulin Secretion in
(2011)
β-cells found in the islets of Langerhans secrete insulin in response to elevated blood glucose levels. Disruption of this process causes diabetes which is characterized by poor control of blood glucose and results in ...
I. Synthesizing and Identifying Small Molecule Probes for Targeting Transcriptional Co-factors II. Design and Implementation of a Peer-Led Practical Research Ethics Module for Teaching Graduate Research Ethics.
(2011)
Activated transcription is a complex process that is governed by the interactions of several different proteins. As misregulation of transcription has been observed in many diseases, understanding the roles of the proteins ...
Implantable Amperometric Glucose/Lactate Sensors with Nitric Oxide Release/ Generation Coatings for Enhanced Biocompatibility and Needle-Type Glucose Sensor for Tear Glucose Measurements.
(2011)
One of the greatest technological challenges of implantable biosensors is the biocompatibility problem that arises after implantation. Nitric oxide (NO) is known as a potent anti-thrombus and anti-inflammatory agent ...
Protein Expression and Glycosylation Level Change Associated Pancreatic Cancer.
(2010)
The discovery of molecular markers that distinguish certain diseases has improved the sensitivity and accuracy of diagnosis and contributed to the development of new therapeutic targets. Pancreatic cancer, as the most ...
Synthesis and Reactivity of Palladium Trifluorides and Fluorides Towards Aryl C-CF3 and C-F Bond Formation.
(2011)
The installation of carbon–fluorine and carbon-trifluoromethyl bonds in organic compounds can have a significant effect on the chemical and biological of the molecules. However, synthetically the selective incorporation ...
Quantum Optical Applications in Spectroscopy: Investigations of Entangled Two-Photon Absorption and Entangled Two-Photon Excited Fluorescence in Organic Dendritic Systems.
(2010)
Entangled states of light have been utilized successfully in a wide variety of experiments and applications. This dissertation will discuss the application of entangled states of light toward spectroscopy wherein entangled ...
Gas-phase Ion-electron and Ion-photon Reactions for Structural Characterization of Protein Glycosylation.
(2011)
Glycosylation is one of the most prevalent post-translational modifications (PTMs), playing key roles in various biological activities. Characterization of protein glycosylation faces unique challenges due to the highly ...
Method Development and Mechanistic Investigation of Nickel-Catalyzed Reductive Coupling Processes.
(2010)
Many classes of standard organic transformations involve the coupling or cycloaddition of two different π-components to assemble a more functionalized product. Many such processes are amenable to the union of two complex ...
Expanding the Repertoire of Chemical Modulators for Heat Shock Protein 70 (Hsp70): New Probes for Neurodegenerative Disease.
(2010)
Heat shock protein 70 (Hsp70) is a molecular chaperone that plays pivotal roles in protein homeostasis in nearly all organisms. In these roles, Hsp70 binds to newly synthesized or misfolded proteins and regulates their ...
Multicompartmental Biomaterials via Electrohydrodynamic Co-jetting.
(2011)
The synthesis and theranostic applications of biodegradable anisotropic materials are described in this dissertation. Precise nano- and micro-scale control of the architecture of biodegradable polymeric materials is highly ...