Now showing items 4991-5000 of 5036
YfeX – A New Platform for Carbene Transferase Development with High Intrinsic Reactivity
(SpringerWiley Periodicals, Inc., 2022-11-21)
Carbene transfer biocatalysis has evolved from basic science to an area with vast potential for the development of new industrial processes. In this study, we show that YfeX, naturally a peroxidase, has great potential for ...
Reply to Correspondence on “Synergy and Antagonism between Allosteric and Active-Site Inhibitors of Abl Tyrosine Kinase”
(Wiley Periodicals, Inc., 2022-11-14)
Manley and co-workers provide data demonstrating that, at super-pharmacological concentrations (300 μM), a ternary complex between Abl, asciminib, and ATP-competitive inhibitors is possible. The work in our manuscript ...
Reply to Correspondence on “Synergy and Antagonism between Allosteric and Active-Site Inhibitors of Abl Tyrosine Kinase”
(Wiley Periodicals, Inc., 2022-11-14)
Manley and co-workers provide data demonstrating that, at super-pharmacological concentrations (300 μM), a ternary complex between Abl, asciminib, and ATP-competitive inhibitors is possible. The work in our manuscript ...
Photochemical C(sp2)−H Pyridination via Arene–Pyridinium Electron Donor–Acceptor Complexes
(Wiley Periodicals, Inc., 2022-11-14)
This report describes the development of a photochemical method for C(sp2)−H pyridination that leverages the photoexcitation of electron donor–acceptor (EDA) complexes. Experimental and DFT studies show that black light ...
Effect of Nanoscale Confinement on Ultrafast Dynamics of Singlet Fission in TIPS-Pentacene
(WILEY-VCH, 2022-11-18)
Singlet fission (SF) is a phenomenon for the generation of a pair of triplet excitons from anexcited molecule in singlet electronic state interacting with another adjacent molecule in its ground electronic state. By ...
Watching Excited State Dynamics with Optical and X-ray Probes: The Excited State Dynamics of Aquocobalamin and Hydroxocobalamin
(American Chemical Society, 2023-06-16)
Femtosecond time-resolved X-ray absorption (XANES) at the Co K-edge, X-ray emission (XES) in the Co Kβ and valence-to-core regions, and broadband UV–vis transient absorption are combined to probe the femtosecond to picosecond ...
Exploring Novel Enzyme Activity and Genetic Diversity Through Biocatalytic Engineering and Microbiome Mapping
(2021)
Nature provides us with a wealth of natural product molecules and biological catalysts that represent a rich source of new life-saving pharmaceutical medicines and biotechnological tools for green chemistry. The synthetic ...
Physical Organic Approach Towards High-Performance Materials for Non-Aqueous Redox Flow Battery
(2021)
Redox flow batteries (RFBs) are a promising technology for grid-scale energy storage of renewable energy resources. Aqueous RFBs have been studied extensively and have resulted in the development of promising commercial ...
Unique Dimerization Topology and Countercation Binding Modes in 12-Metallacrown-4 Compounds
(Wiley-VCH Verlap & Co. KGaA, 2022-11-17)
Seven dimeric metallacrowns (MC) based on Ln[12-MCM(III)N(shi)-4], where LnIII=Dy, Ho, Yb, or Y, MIII=Mn or Ga, and shi3− is salicylhydroximate, have been synthesized and characterized by single-crystal X-ray diffraction, ...
NetCellMatch: Multiscale Network-Based Matching of Cancer Cell Lines to Patients Using Graphical Wavelets
(Wiley Periodicals, Inc., 2022-12)
Cancer cell lines serve as model in vitro systems for investigating therapeutic interventions. Recent advances in high-throughput genomic profiling have enabled the systematic comparison between cell lines and patient tumor ...