Now showing items 5001-5010 of 5058
Copolymers to Stabilize Morphology in Conjugated Polymer-Fullerene Blends and Understanding Alkene Spacing for Repurposing Polyethylene via Alkane Metathesis and Cyclodepolymerization
(2021)
It is indisputable that human activity has warmed Earth’s oceans, land, and atmosphere, posing challenges for human and non-human life. To mitigate the effects of climate change, more sustainable technologies and systems ...
Development of Structural and Synthetic Tools to Determine the Structure of the Active Ni(I) State of Methyl-Coenzyme M Reductase:Nature's Catalyst for Methane Synthesis, Activation, and Oxidation
(2023)
Methyl-Coenzyme M Reductase (MCR) catalyzes the forward and reverse reactions of methane biosynthesis and anaerobic methane oxidation, respectively. MCR employs radical chemistry via the catalytic Ni cofactor F430, where ...
Benzothiophene-based Fragments Act as Reversible and Irreversible Covalent Probes for Dynamic Coactivator Med25
(2023)
Transcriptional coactivators mediate transcriptional activity within cells by forming transient protein-protein interactions (PPIs) to facilitate the assembly of the RNA polymerase machinery. Dysregulation of these PPIs ...
Improved Liquid Chromatography-Mass Spectrometry Approaches for Characterization of Therapeutic RNA
(2023)
This dissertation focuses on extending and improving current applications of liquid chromatography-mass spectrometry (LC-MS) for therapeutic oligonucleotides (ONs), which continue to grow in both clinical importance and ...
Ultrafast X-ray Absorption Spectroscopy Reveals Excited State Dynamics of B12 Coenzymes Controlled by the Axial Base
(American Chemical Society, 2023-11-23)
Polarized time-resolved X-ray absorption spectroscopy at the Co K-edge is used to probe the excited state dynamics and photolysis of base-off methylcobalamin and the excited state structure of base-off adenosylcobalamin. ...
Binary Mixtures in Linear Convection Arrays
(Wiley Periodicals, Inc.(Springer Netherlands, 2023-01-03)
We numerically investigated the dynamics of a mixture of finite-size active and passive disks in a linear array of two-dimensional convection rolls. The interplay of advection and steric interactions produces a number of ...
Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms
(Wiley Periodicals, Inc., 2023-01)
It is challenging to study regulatory genetic variants as gene expression is affected by both genetic polymorphisms and non-genetic regulators. The mRNA allele-specific expression (ASE) assay has been increasingly used for ...
3D Islet Assay Development and SAR of Chromenones for Beta-Cell Replenishment
(2023)
Diabetes poses a global health crisis affecting individuals across age groups and backgrounds, with a prevalence estimate of 700 million people worldwide by 2045. Current therapeutic strategies primarily rely on insulin ...
Charge and Proton Transport in Electrocatalysis by Polymer Encapsulated Cobalt Phthalocyanine
(2022)
The electrocatalytic CO2 reduction reaction (CO2RR) is one proposed method to convert industrial waste CO2 into value-added products using renewable electricity. There are many (photo)electrocatalysts that can decrease ...