Now showing items 241-245 of 245
The Function of the ASH1L Histone Methyltransferase in Cancer: A Chemical Biology Approach
(2018)
ASH1L (absent, small, or homeotic-like 1) is a histone lysine methyltransferase (KMTase) that is overexpressed in cancer and activates oncogenic HOX genes. Small molecule inhibitors of ASH1L would be invaluable tools to ...
Identifying Optimal Anemia Management Practices in Hemodialysis
(2019)
Optimal anemia management strategies for end-stage kidney disease patients treated with hemodialysis are unknown, with controversies over how best to utilize erythropoiesis-stimulating agents (ESA) and intravenous iron to ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Role of CHD7 in Neural Development and Maintenance.
(2011)
Normal tissue development and maintenance require precise timing and correct localization of gene expression. Several lines of evidence indicate that the chromodomain (CHD) family of proteins are critical regulators of ...
Case studies in bias reduction and inference for electronic health record data with selection bias and phenotype misclassification
(John Wiley & Sons, Inc., 2022-12-10)