Now showing items 11-20 of 65
Transcriptomic Profiling Reveals Novel Shear Stress-sensitive Genes in Human Endothelial Cells.
(2016)
Atherosclerosis is recognized as the pathological basis of ischemic heart disease and stroke, two leading causes of death worldwide. Shear stress generated from blood flow plays a key role in the development of atherosclerosis. ...
Design, Synthesis and Biological Evaluation of Non-Peptidic Small Molecular SMAC Mimetics as Potent IAP Inhibitors.
(2008)
The resistance of tumor cells to apoptosis is a major problem in current cancer therapies. Successful anticancer strategies would benefit from specific targeting of the pathways that cause the resistance. Hence, targeting ...
Proteolytic Profiling with Imaging Agents for Rational Design of Target-Activated Peptide Prodrugs.
(2012)
Peptide prodrugs can be used to alter pharmacokinetic properties of drugs such improved oral bioavailability and site-specific delivery. This thesis focuses on peptide prodrug activating enzymes and selection of peptide ...
GABAA Receptors in the Pontine Reticular Formation of C57BL/6J Mouse Modulate Neurochemical, Electrographic,and Behavioral Phenotypes of Wakefulness.
(2010)
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain and many drugs used to produce sleep, sedation, or general anesthesia enhance transmission at GABA-A receptors (GABA-ARs). The mechanisms ...
Regulation of the D2-Like Dopamine Autoreceptor by the Dopamine Transporter.
(2014)
Despite its relatively low abundance in the brain, the neurotransmitter dopamine (DA) is vitally important for controlling motor coordination, motivation, reward, and cognition, among other processes. The amount of DA in ...
Methodological Advances for Drug Discovery and Protein Engineering
(2018)
Designing and engineering molecules that have specified properties not only test our understanding of nature but also play an important role in improving both human health and industrial productivity. Two such examples are ...
Mechanistic Model-based Drug Oral Absorption Analysis
(2021)
The thesis research consists of two projects: the major focus is using population approach to account for the systemic availability variability of Mycophenolate Mofetil (MMF) in human and providing insights into developing ...
Inhibiting the Actions of Essential Biomolecule Phosphopantetheine.
(2015)
Phosphopantetheine is an essential biomolecule required for life. The enzyme phosphopantothenoylcysteine synthetase (PPCS) incorporates the reactive thiol moiety in the Coenzyme A (CoA) biosynthetic pathway. Two types of ...
Novel Modulators of Rho Transcriptional Signaling in Cancer.
(2012)
Rho A and Rho C, members of the Rho GTPase family, have been found to have important roles in the metastases of multiple cancers, including melanoma, prostate, and breast cancer. While Rho GTPases are known to have effects ...
Investigating Endothelial Dysfunction in a CRISPR/Cas9 Model of Fabry Disease
(2017)
Fabry disease is a rare, X-linked lysosomal storage disease arising from deficiency of the lysosomal hydrolase, α-galactosidase A (GLA). Reduced GLA activity disrupts glycosphingolipid (GSL) catabolism, leading to widespread ...