Now showing items 51-60 of 65
Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone.
(2013)
Damm et al. utilized a multiple protein structure (MPS)-based method and discovery an allosteric site of HIV-1 protease (HIV-1p) that had not been described before. Based on this new site, a MPS-based pharmacophore model ...
Construction of Engineered Nanoparticles with Tailored Densities of Self-Antigen for the Study of B-cell Activation
(2019)
Epitope density appears to be a critical factor in pathogens that can elicit effective immune responses. All the viruses that have efficacious FDA-approved target vaccines have high surface densities of antigens. HIV, on ...
Identifying Optimal Anemia Management Practices in Hemodialysis
(2019)
Optimal anemia management strategies for end-stage kidney disease patients treated with hemodialysis are unknown, with controversies over how best to utilize erythropoiesis-stimulating agents (ESA) and intravenous iron to ...
Development of Small Molecule RGS Inhibitors as a Mechanism to Modulate G-Protein Signaling.
(2010)
Regulator of G-protein Signaling (RGS) proteins are important regulatory molecules in the transduction of G-Protein Coupled Receptor (GPCR) signaling. They function by directly binding to G alpha subunits and accelerating ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Characterization of Human Hsp70 Chaperone Complexes and Chemical Control Over Their Formation.
(2012)
Heat shock protein 70 (Hsp70) is a molecular chaperone that plays a central role in cellular protein homeostasis by assisting in the folding and/or degradation of protein substrates. In these tasks, Hsp70 is assisted by ...
Factors Influencing Opioid Receptor Signaling to Adenylyl Cyclase.
(2010)
Opioids, such as morphine, signal through G protein-coupled receptors that are linked to adenylyl cyclase (AC)-inhibitory (Gi/o) heterotrimeric GTP-binding proteins. The transduction of signal from opioid receptor to G ...
The Role of SUMO Modification in the Regulation of Kv1.5, a Major Cardiovascular Potassium Channel.
(2010)
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the United States. A major limitation to current antiarrhythmic medications used to treat AF is the occurrence of potentially life-threatening, proarrhythmic, ...
PTD-Mediated Red Blood Cell Encapsulation of L-Asparaginase for Potential Treatment of Acute Lymphoblastic Leukemia.
(2010)
One of the primary drugs used in treatment of acute lymphoblastic leukemia is L-asparaginase (ASNase), which despite its therapeutic efficacy, faces challenges often faced in protein drug treatment: the immunogenicity and ...
SMARTS Approach to Chemical Data Mining and Physicochemical Property Prediction.
(2009)
The calculation of physicochemical and biological properties is essential in order to facilitate modern drug discovery. Chemical spaces dimensionalized by these descriptors have been used to scaffold-hop in order to discover ...