Now showing items 11-20 of 88
The Application of Mass Spectrometry-Based Label-Free Quantitative Proteomic Strategies in Cancer Stem Cell Research.
(2011)
The application of mass spectrometry(MS) has dramatically expanded the frontiers of the analysis of protein expression in biological samples. This thesis addresses the application of a MS-based label-free strategy to analyze ...
Exploring a "Nature-Inspired" Strategy for Enhancing the Pharmacology of Small Molecules: Towards the Development of Next Generation Anti-Infectives.
(2011)
HIV is now a pandemic of staggering proportions. Unfortunately, the current generation of antiretroviral therapeutics is only partially and temporarily effective in suppressing viral replication due to rapid metabolism ...
Protein Flexibility in Structure-Based Drug Design: Method Development and Novel Mechanisms for Inhibiting HIV-1 Protease.
(2007)
Structure-based drug design (SBDD) has emerged as an important tool in drug discovery research. Traditionally, SBDD is based on a static crystal structure of the target protein. However, a protein in solution exists as an ...
Mapping, Tracking and Modeling the Movements of Single Membrane-Bound Transcription Activator Proteins in Live Vibrio cholerae.
(2014)
Cholera has been known since ancient times, yet there is still no cure. Vibrio cholerae bacteria cause cholera by producing cholera toxin. Cholera toxin production is regulated by the protein ToxT, which itself is regulated ...
Low-Flow Push-Pull Perfusion for Measuring Neurotransmitters with High Spatial and Temporal Resolution within the Living Brain.
(2013)
Low-flow push-pull perfusion is a technique for measuring neurotransmitters within the brain with ~200 μm resolution. Activity of neurotransmitters can vary on this size scale; therefore, low-flow push-pull may offer new ...
Understanding the Optical and Photophysical Properties of Organic and Hybrid Macromolecules and Polymers for Solar Cell Application
(2021)
Organic solar cell materials represent a better sustainable alternative relative to inorganic materials in terms of lower cost, ease of large-scale processing, better absorptivity, ease of tunability, and unique flexibility ...
Synthesis and Characterization of Microporous Coordination Polymers as Adsorbents for CO2 Capture.
(2012)
The accumulation of CO2 in the Earth’s atmosphere is an important environmental issue, and coal-fired power plants are significant contributors to anthropogenic CO2 emissions. The capture of CO2 from these facilities via ...
Folate Binding Protein as a Therapeutic Natural Nanotechnology
(2018)
Serum proteins interact with small molecules and nanoparticles in blood, resulting in protein coronas. Protein coronas influence the bioidentity of the molecules and nanoparticles, playing critical roles in biotransport, ...
Continuum-Scale Modeling of Rechargeable Batteries
(2020)
During the operation of a rechargeable battery, the electrochemical reactions occur at the interface between the electrolyte and the active material in the electrode. The electrochemical performance of such batteries is ...
Growth, Characterization and Assembly of Lead Chalcogenide Nanosemiconductors for Ionizing Radiation Sensors
(2022)
The demand for precise and efficient nuclear radiation detection has increased dramatically, particularly in numerous scientific disciplines, as well as homeland security and medical imaging applications. Modern methods ...