Now showing items 21-30 of 39
Cultivation of Enhanced Bioinformatic-Specific Pedagogical Manipulatives, Interventions, and Professional Development
(2022)
The education of bioinformatics, as an interdisciplinary science, can be negatively impacted by 1) incoming students attempting to negotiate complex concepts while lacking the educational scaffolding of the field’s constituent ...
Design and Testing Novel Wearable Instrumentation for Assessing Pelvic Floor Function and Exploring Continence Mechanisms
(2020)
Urinary incontinence (UI) and fecal incontinence (FI) affect 20% of North Americans, with a higher prevalence in women and the elderly. The prevention and treatment of these conditions unfortunately leaves much to be ...
The Influence of Idiopathic Chronic Neck Pain on Sternocleidomastoid and Upper Trapezius Muscle Activity and Elasticity
(2022)
Approximately half of all adults will experience neck pain. Without early detection and proper treatment, neck pain will likely become chronic. Chronic neck pain is one of the primary causes of disability in the United ...
Biological Applications of Surfaces with Extreme Wettabilities
(2019)
Surfaces with extreme wettabilities have become an increasingly popular topic due to their wide range of applications – from simply keeping dirt off clothing to oil-water separation in the event of an oil spill. In particular, ...
In Vitro and In Vivo Testing of Ultra-Small Gold Nanoparticles as a Novel Drug Delivery Platform for Enhancing the Brain Penetration and Receptor Binding Affiinity of Central Nervous System Drugs.
(2013)
The endothelial cells of brain capillaries form the so-called blood brain barrier (BBB) which protects the central nervous system (CNS) from the entry of neurotoxins and blood components. Consequently, more than 98% of ...
Multiscale Modeling of T Cells in Mycobacterium Tuberculosis Infection
(2021)
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (Mtb), is one of the deadliest infectious diseases in the world and remains a significant global health burden. Central to the immune response against ...
Microfluidic Technologies for Bioanalytical Chemistry: Advancing Epigenetic Profiling via Chromatin Immunoprecipitation in Droplets
(2019)
Beyond the linear sequence of the genome, the epigenome dynamically controls chromatin remodeling and transcriptional poise without inducing changes in DNA sequence. These epigenetic mechanisms, particularly modifications ...
Multidisciplinary Study of Soft Shape Morphing Systems
(2021)
Nature abounds with examples of shape morphing systems where an entity either gradually grows into a complex 3-D shape pattern or rapidly morphs into a new configuration. Inspired by the shape shifting capabilities of ...
To Be, or Not to Be: Cellular Homeostasis to Mechanical Perturbations
(2016)
Mechanical homeostasis is an emerging mechanobiology concept that describes the critical biological process to maintain whole-cell/tissue physiology against forces and deformation arising both intra- and extracellularly. ...
Understanding the Solution Phase Chemistry and Solid State Thermodynamic Behavior of Pharmaceutical Cocrystals.
(2012)
This dissertation focuses on the thermodynamic stability and solubility of pharmaceutical cocrystals. Specifically, the objectives are to; (i) investigate the influence of coformer properties such as solubility and ionization ...