Now showing items 311-320 of 324
Developing Pseudo-Observation and Multiple Imputation Approaches for Analysis of Dependently Censored Survival and Quality-Adjusted Survival Data.
(2012)
Dependent censoring is a common issue in survival and quality-adjusted survival analysis. This thesis develops pseudo-observation and multiple imputation approaches for analysis of these types of data. Our motivating ...
Bayesian Methods for SMART Designs With Re-Randomization Based on a Continuous Outcome and Estimating Survival Outcomes When COVID-19 Is a Competing Risk in Cancer Patients
(2021)
Sequential, multiple assignment, randomized trials (SMARTs) typically rely on a binary variable to define response which is used in assigning the next stage treatment assignment. We develop a function of a continuous outcome ...
Data-Driven Environmental System Analysis: Addressing Data Gaps in Life Cycle Assessment
(2019)
Life Cycle Assessment (LCA) is a widely used analytical tool in environmental system analysis. LCA examines the environmental impacts of a product along its whole life cycle, including raw materials extraction, manufacturing, ...
Identifying Optimal Anemia Management Practices in Hemodialysis
(2019)
Optimal anemia management strategies for end-stage kidney disease patients treated with hemodialysis are unknown, with controversies over how best to utilize erythropoiesis-stimulating agents (ESA) and intravenous iron to ...
Models for Survival and Longitudinal Data in Cancer Research.
(2010)
In the field of survival analysis, we often encounter the situation where a fraction of the study subjects will never experience an event. Cure models have been formulated to address this issue. We developed a family of ...
Estimation and Inference in High Dimensional Networks, with Applications to Biological Systems.
(2010)
This dissertation discusses several aspects of estimation and inference for high dimensional networks, and is divided into three main parts. First, to assess the significance of arbitrary subnetworks (e.g. pathways), I ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Integrative Statistical Methods for the Analysis of Transcriptomic and and Metabolomic Data.
(2010)
Cancer research is embracing the multiple``-omics'' technologies available for global scale measurement of molecular events. Transcriptomics, as the global measure of gene expression, has been well developed through ...
Methods for statistical and population genetics analyses.
(2011)
Genetics studies have advanced rapidly, from candidate region studies to genome wide association studies (GWAS) and next generation sequencing projects. The emergence of new technologies has brought with it an array of ...
Chemometric Methods for the Determination of Volatile Organic Compounds with Microsensor Arrays.
(2008)
This research addresses critical chemometric modeling and data analysis functions needed to guide the design and implementation of novel meso-scale and micro-scale instrumentation that incorporates chromatographic separation ...