Now showing items 1-6 of 6
The effect of phenotype variation on detection of linkage in the COGA data
(Wiley Subscription Services, Inc., A Wiley Company, 1999)
Error in phenotypic measurement can significantly compromise ability to detect linkage. We assessed the impact of introducing phenotypic measurement error on our ability to detect a quantitative trait locus in the Collaborative ...
Application of an ordered subset analysis approach to the genetics of alcoholism
(Wiley Subscription Services, Inc., A Wiley Company, 1999)
For complex diseases, underlying etiologic heterogeneity may reduce power to detect linkage. Thus, methods to identify more homogeneous subgroups within a given sample in a linkage study may improve detection of putative ...
Metanephric rat-mouse chimeras to study cell lineage of the nephron
(John Wiley & Sons, Inc., 1999)
The nephron is derived from the ureteric bud and metanephric mesenchyme and develops into a complex epithelial structure with a wide variety of phenotypes along its length. This segmental variation in expression of molecules ...
Kidney development branches out
(John Wiley & Sons, Inc., 1999)
For more than 40 years now, the developing kidney has served as a model paradigm for epithelial-mesenchymal interactions. The principles of inductive signaling, epithelial cell differentiation, and pattern formation are ...
Identifying influential individuals in linkage analysis: Application to a quantitative trait locus detected in the COGA data
(Wiley Subscription Services, Inc., A Wiley Company, 1999)
Once linkage is detected to a quantitative trait locus (QTL), the next step towards localizing the gene involved may be to identify those families, or individuals, in whom the putative mutations are segregating. In this ...