Now showing items 1-10 of 17
Discordant and heterogeneous clinically relevant genomic alterations in circulating tumor cells vs plasma DNA from men with metastatic castration resistant prostate cancer
(John Wiley & Sons, Inc., 2020-04)
Circulating tumor cell (CTC) and cellâ free (cf) DNAâ based genomic alterations are increasingly being used for clinical decisionâ making in oncology. However, the concordance and discordance between paired CTC and cfDNA ...
Single nucleotide polymorphism array and cytogenetic analyses of ovarian teratomas in children
(John Wiley & Sons, Inc., 2021-06)
Teratomas are the most common tumors in the ovary during childhood. Previous studies suggested that they may be derived from germ cells at any developmental stage from premeiotic oogonia through meiotic oocytes to post‐meiotic ...
Telomere-mediated genomic instability and the clinico-pathological parameters in breast cancer
(Wiley Subscription Services, Inc., A Wiley Company, 2008-12)
A study was undertaken to correlate telomere dysfunction and genomic instability with the histopathological grades and the estrogen and progesterone receptor status in breast cancer. Sixty-one archived breast tissues (38 ...
Cytogenomic array detects a subset of myelodysplastic syndrome with increased risk that is invisible to conventional karyotype
(John Wiley & Sons, Inc., 2019-11)
Conventional karyotyping is essential standard practice in the initial evaluation of myelodysplastic syndrome (MDS) and is the most impactful single component of the Revised International Prognostic Scoring System (IPSS‐R). ...
Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia
(Wiley Subscription Services, Inc., A Wiley Company, 2012-12)
A subset of chronic lymphocytic leukemia (CLL) carries mutations in ataxia telangiectasia mutated ( ATM ). Such ATM mutations may be particularly relevant in the setting of del11q, which invariably results in the deletion ...
Ovarian steroid cell tumor with biallelic adenomatous polyposis coli inactivation in a patient with familial adenomatous polyposis
(Wiley Subscription Services, Inc., A Wiley Company, 2012-03)
Familial adenomatous polyposis (FAP) is an autosomal dominant cancer predisposition syndrome that accounts for approximately 0.5–1% of all colorectal cancer cases. It is caused by germline mutations in the gene encoding ...
SEPT9_i1 and genomic instability: Mechanistic insights and relevance to tumorigenesis
(Wiley Subscription Services, Inc., A Wiley Company, 2011-11)
Septins are highly conserved cytoskeletal GTP‐binding proteins implicated in numerous cellular processes from apoptosis to vesicle trafficking. Septins have been associated with leukemia and solid tumor malignancies, ...
Stably transfected common fragile site sequences exhibit instability at ectopic sites
(Wiley Subscription Services, Inc., A Wiley Company, 2008-10)
Common fragile sites (CFSs) are loci that are especially prone to forming gaps and breaks on metaphase chromosomes under conditions of replication stress. Although much has been learned about the cellular responses to gaps ...
Specific extra chromosomes occur in a modal number dependent pattern in pediatric acute lymphoblastic leukemia A complete listing of grant support for research conducted by CCG and POG before initiation of the COG grant in 2003 is available online at: http://www.childrensoncologygroup.org/admin/grantinfo.htm
(Wiley Subscription Services, Inc., A Wiley Company, 2007-07)
Children with acute lymphoblastic leukemia (ALL) and high hyperdiploidy (>50 chromosomes) are considered to have a relatively good prognosis. The specific extra chromosomes are not random; extra copies of some chromosomes ...
Characterizing and Targeting the Chromatin Determinants of Cancer Cell Identity: Cancer's Addiction to its Originating Cellular Lineage
(2021)
Cancer is a complex disease that is initiated by genetic perturbations in normal cells leading to uncontrollable cellular division. The ensuing tumor mass, at both primary and distant metastatic sites, hinders the normal ...