Now showing items 1-6 of 6
Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling
(Wiley Periodicals, Inc.Humana, 2020-09)
Several metabolites serve as substrates for histone modifications and communicate changes in the metabolic environment to the epigenome. Technologies such as metabolomics and proteomics have allowed us to reconstruct the ...
Understanding Human Lung Development through In Vitro Model Systems
(Wiley Periodicals, Inc., 2020-06)
An abundance of information about lung development in animal models exists; however, comparatively little is known about lung development in humans. Recent advances using primary human lung tissue combined with the use of ...
The Anti‐G0 Manifesto: Should a problematic construct (G0) with no biological reality be removed from the cell cycle? Yes!
(Wiley Periodicals, Inc., 2021-03)
It is widely accepted that there exists a “resting” or “quiescent” state where a growing cell leaves the cell cycle to enter what is often called the “G0‐phase.” I propose that there is no biological reality to the “G0‐phase.” ...
Bone regeneration via skeletal cell lineage plasticity: All hands mobilized for emergencies
(Wiley Periodicals, Inc., 2021-01)
An emerging concept is that quiescent mature skeletal cells provide an important cellular source for bone regeneration. It has long been considered that a small number of resident skeletal stem cells are solely responsible ...
Molecular Investigation of Human-Specific Neurobiology: From Cortical Evolution to Neurodevelopmental Disorders
(2022)
The human brain evolves under a unique set of adaptive pressures, distinguishing aspects of form and function from the brains of other primate species. An outstanding question in evolutionary biology is the biological ...
Pleiotropic Effects of Cis- And Trans-Regulatory Mutations
(2021)
Changes in gene expression are an important source of phenotypic diversity both within and between species. Mutations generating variation in gene expression can be cis-regulatory to a particular gene, which typically occur ...