Now showing items 1-8 of 8
Mechanistic Dissection of DNA Repair Pathways in Bacillus subtilis.
(2014)
All cells must accurately copy and maintain their DNA to ensure the faithful transmission of their genetic material to the next generation. Organisms ranging from bacteria to humans contain a suite of DNA repair pathways ...
Inside or Out: Characterizing petrobactin use by Bacillus anthracis
(2018)
Bacillus anthracis is a Gram-positive, spore-forming bacillus and causes the disease anthrax. Anthrax is a deadly infection that begins with phagocytosis of a B. anthracis spore by an antigen presenting cell and ends when ...
Roles for GLI Transcription Factors in Pancreas Development and Disease
(2022)
The Hedgehog (HH) signaling pathway plays a fundamental role in patterning numerous developing tissues, and dysregulated HH signaling has been linked to malignant human diseases. HH signaling is regulated on a transcriptional ...
A Longitudinal and Transancestral Analysis of DNA Methylation Patterns in Systemic Lupus Erythematosus
(2022)
Objective: Systemic lupus erythematosus (SLE or lupus) is a complex heterogeneous autoimmune disease that can affect multiple organ systems. Lupus predominantly affects women, with African-American women carrying higher ...
PSM Small Peptide Toxins Form Functional Bacterial Amyloids in the Staphylococcus aureus Biofilm Matrix.
(2014)
Staphylococcus aureus is a Gram-positive opportunistic pathogen colonizing mammalian hosts. Like many bacteria, S. aureus forms multicellular aggregates called biofilms. Biofilms are surface-associated communities of ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
The Application of Genetic, In Silico and In Vitro Tools to Elucidate the Biology of a Functional Amyloid Fiber.
(2010)
Curli are thin aggregative fimbriae produced by many Enterobacteriaceae as a structural component of biofilms. Curli share many biochemical and biophysical properties with amyloid fibers which are often associated with ...
Directed Evolution Designed to Optimize the in vivo Protein Folding Environment.
(2010)
Protein folding is assisted by molecular chaperones and folding catalysts in vivo. Understanding how chaperones are regulated and how they function in vivo may provide new avenues for developing protein folding modulators. ...