Now showing items 1111-1118 of 1118
Contributions of the Bone Marrow Microenvironment to Bone and Skeletal Metastasis.
(2015)
The skeleton, a favored organ for prostate cancer is organized by a mineralized connective tissue, and a rich marrow where hematopoiesis replenishes a variety of blood cells and gives rise to many cell populations. Thus, ...
Isolation and Characterization of Circulating Biomarkers to Predict Patient Outcomes in Late-Stage Non-Small Cell Lung Cancer
(2021)
This work hypothesizes that the molecular characterization of extracellular vesicles (EVs) and circulating tumor cells (CTCs), biomarkers found in peripheral blood draws, can be used to monitor, and predict, treatment ...
Chemical Modulation of Phospho-Signaling Pathways Involved in Cancer.
(2015)
Advancements in our understanding of the molecular causes of cancer have led to the therapeutic targeting of key enzymes involved in cell growth. Kinase inhibitors have been the most successful forms of such targeted therapy ...
Investigating the Role of HIP1/PDGFβR in Leukemogenesis and Imatinib Sensitivity
(2012)
The Huntingtin interacting protein 1 (HIP1)-platelet-derived growth factor beta receptor (PDGFβR) fusion oncogene (H/P), resulting from a somatic t(5;7) translocation, causes expression of a constitutively active tyrosine ...
Alternative Androgen Metabolism in Resistance to Aromatase Inhibitors.
(2011)
The treatment of estrogen-receptor positive breast cancer is based on endocrine therapy, with aromatase inhibitors (AIs) serving as the current front-line therapy in post-menopausal women. Despite prolonging disease-free ...
Incidence and management of pleural effusions in patients with Wilms tumor: A Pediatric Surgical Oncology Research Collaborative study
(John Wiley & Sons, Inc., 2022-11-15)
Wilms tumor (WT) is the most common renal malignancy in children. Children with favorable histology WT achieve survival rates of over 90%. Twelve percent of patients present with metastatic disease, most commonly to the ...
Prevention Strategies for Gynecologic Cancers
(2022)
This dissertation focused on prevention strategies for ovarian and cervical cancers. Primary prevention of ovarian cancer was explored in Aim 1 using data from the Ovarian Cancer Association Consortium (OCAC; 7,743 cases; ...
Engineering Multifunctional Nanoparticles: Applied Nanoscale Therapeutics
(2022)
Decades of research towards the development of nanomedicines have, to date, yielded minimal
clinical impact. Focused particularly on the treatment of cancer, the relatively low
number of pursued technologies to reach the ...