Now showing items 11-20 of 54
Combination vinorelbine and capecitabine for metastatic breast cancer using a non-body surface area dosing scheme
(Springer-Verlag, 2006-07)
Purpose : This study sought to determine the maximum tolerated dose of flat-dosed vinorelbine in combination with capecitabine in patients with metastatic breast cancer. At the time of study initiation, it was anticipated ...
Phase II Trial of Docetaxel Chemotherapy in Patients with Incurable Adenocarcinoma of the Esophagus
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-02)
Background : Chemotherapy remains theprimary mode of treatment for metastaticcarcinoma of the esophagus. The efficacyof various chemotherapeutic regimens hasbeen studied predominantly in patients withsquamous cell carcinoma ...
A phase II trial of aclacinomycin-A in advanced squamous cell carcinoma of the head and neck
(Kluwer Academic Publishers; Martinus Nijhoff Publishers ; Springer Science+Business Media, 1985-12)
Sixteen patients with advanced squamous cell carcinoma of the head and neck were entered into a phase II trial of Aclacinomycin-A (ACM), 100 mg/M 2 administered by brief infusion every three weeks. All patients had received ...
Cisplatin, VP-16-213 and MGBG (Methylglyoxal bis guanylhydrazone) combination chemotherapy in refractory lymphoma, a phase II study
(Kluwer Academic Publishers; Springer Science+Business Media, 1988-09)
In an effort to improve the treatment of patients with refractory or recurrent lymphoma, we developed a protocol using cis-platinum combined with two other agents of known efficacy in these disorders but with differing ...
The role of p53 in gemcitabine-mediated cytotoxicity and radiosensitization
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-04)
Purpose : We compared the cytotoxic and radiosensitizing effects of gemcitabine (2′,2′-difluoro-2′-deoxycytidine, dFdCyd), a clinically valuable radiosensitizer, in colon cancer RKO cells which differed in their p53 status. ...
Dependence of fluorodeoxyuridine-induced cytotoxicity and megabase DNA fragment formation on S phase progression in HT29 cells
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1996-02)
The relationship between cell cycle progression and induction of DNA double-strand breaks and cytotoxicity by exposure to fluorodeoxyuridine (FdUrd) was studied in HT29 human colon cancer cells. Fractionation of drug-treated ...
Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model
(Springer-Verlag, 2005-02)
The purposes of this study were to determine the effect of structural change on the intestinal disposition of isoflavones and to elucidate the mechanisms responsible for transport of phase II isoflavone conjugates. Transport ...
Evaluation of menogaril in renal cell carcinoma
(Kluwer Academic Publishers; Springer Science+Business Media, 1990-03)
The Southwest Oncology Group (SWOG) studied the response rate and toxicity of menogaril (200 mg/m 2 i.v. q 28 days) in patients with advanced metastatic renal cell carcinoma. During the early stage of the trial two partial ...
Phase II evaluation of MGBG in non-small cell carcinoma of the lung
(Martinus Nijhoff, The Hague/Kluwer Academic Publishers; Martinus Nijhoff Publishers ; Springer Science+Business Media, 1983-03)
One hundred and eight patients with non-small cell lung cancer were treated in a Phase II trial with MGBG at a dose of 600 mg/m 2 i.v. weekly. Partial responses were noted in 3/43 patients with adenocarcinoma and 1/40 with ...
Phase I Clinical Trial of 5-Fluoro-Pyrimidinone (5FP), an Oral Prodrug of 5-Fluorouracil (5FU)
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-02)
Purpose: 5-Fluoro-Pyrimidinone (5FP)is an oral pro-drug of 5-Fluorouracil(5FU), and is converted to 5FU by hepaticaldehyde oxidase. Preclinically, 5FPdemonstrated anti-tumor activity againstcolon 38 and P 388 leukemia ...