Now showing items 39871-39880 of 41556
Probing Lymphocyte Responses to Modulation of F0F1-ATPase by BZ-423.
(2009)
Bz-423 is an immunomodulatory 1,4-benzodiazepine that binds to the oligomycin sensitivity conferring protein (OSCP) of the mitochondrial F0F1-ATPase and modulates its activity. Inhibition of the F0F1-ATPase by Bz-423 causes ...
Biophysical Determinants of Notch Signaling.
(2009)
Notch signaling is involved in many biological contexts such as cancer, stem cell development, and neural cell development. Because of the importance of Notch function in health and disease, the Notch signaling pathway has ...
The diversity-enhancing effects of plant pathogens: Moving beyond the Janzel-Connell hypothesis to explore how plant species abundance drives the accumulation of pathogen species and the effects of a specialist fungal pathogen on diversity in temperate fo
(2009)
Plant enemies (pathogens and herbivores) have been hypothesized to maintain plant species diversity by causing greater impacts on common species than rare species thus preventing competitive exclusion. While the role of ...
Response of the Elemental Chemistry of Carbonate Phases to Secular Change in Ocean Chemistry.
(2008)
Calcium carbonate is the dominant inorganic mineral precipitate of the global ocean and by no coincidence, it is also the most abundant mineral produced by life. Secular variation in the paleontologic, stratigraphic, ...
CHD8, a Novel ATP-dependent Chromatin Remodeling Enzyme.
(2009)
ATP-dependent chromatin remodeling by the CHD family of proteins plays an important role in the regulation of gene transcription. The CHD family can be subdivided into three families; CHD1-2, CHD3-5, and CHD6-9. While ...
Interactions of Mineral Surfaces and Adsorbates: A Computational Modeling Approach.
(2008)
Calcite and apatite are the two major minerals on the Earth’s surface that interact with organic molecules to create biominerals. We have studied the interaction of small, 3-amino acid peptides and long, 12-amino acid ...
The Cholinesterase-like Domain is Required for Folding and Secretion of Thyroglobulin.
(2008)
Thyroid hormone synthesis requires secretion of thyroglobulin, a precursor protein comprising Cys-rich regions I, II, and III (referred to collectively as regions I-II-III) followed by a cholinesterase-like (ChEL) domain. ...
Evolution of Genes Involved in Mammalian Reproduction and Sex Determination.
(2007)
Traits that influence reproductive success and reproductive isolation in plants and animals have been the central focus of evolutionary biology since Darwin. Many genes were recently identified as important players during ...
Topics in Applied Stochastic Dynamics.
(2009)
Randomness in natural systems come from various sources, for example from the
discrete nature of the underlying dynamical process when viewed on a small scale. In
this thesis we study the effect of stochasticity on the ...
White-Light Generation and OLED Lifetime Issues.
(2008)
This thesis presents experimental results and discussion regarding issues related to organic light-emitting devices (OLEDs). In particular, this thesis has three main focuses: the generation of white light from Förster ...