Now showing items 31-40 of 184
Dual role for the zeste-white3/shaggy -encoded kinase in mesoderm and heart development of Drosophila
(John Wiley & Sons, Inc., 1998)
A Drosophila homolog of the serine/threonine kinase GSK-3β, encoded by the zest-white3/shaggy gene ( zw3 ), has been implicated as a maternally provided antagonist of zygotic signaling by the secreted segmentation gene ...
Chromosomal Localization of Four Human VH1-like Protein-Tyrosine Phosphatases
(Elsevier, 1994-07-15)
Four human protein-tyrosine phosphatase (PTPase) genes of the VH1-like subclass were cloned by low-stringency screening of a genomic library. These genes were localized to their respective chromosomes by G-banding and ...
Determination of the mutations responsible for the lesch-nyhan syndrome in 17 subjects
(Elsevier, 1991-06)
Hypoxanthine -- guanine phosphoribosyltransferase (HPRT) is a purine salvage enzyme that catalyzes the conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. Previous studies of mutant ...
The effect of phenotype variation on detection of linkage in the COGA data
(Wiley Subscription Services, Inc., A Wiley Company, 1999)
Error in phenotypic measurement can significantly compromise ability to detect linkage. We assessed the impact of introducing phenotypic measurement error on our ability to detect a quantitative trait locus in the Collaborative ...
Molecular Characterization of the Murine Neural Retina Leucine Zipper Gene, Nrl
(Elsevier, 1993-11)
The NRL gene (D14S46E) is expressed in cells of human retina and encodes a putative DNA-binding protein of the leucine zipper family. Here we describe the analysis of the murine homolog of the NRL gene, Nrl. Various cDNAs ...
Individual differences in sensitivity to nicotine: Implications for genetic research on nicotine dependence
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1995-03)
Recent evidence suggests that cigarette smoking has a heritability index around 53%. While related research on underlying mechanisms also supports the idea that genetic factors contribute to nicotine dependence—as well as ...
Characterization of the Determinant (traB) Encoding Sex Pheromone Shutdown by the Hemolysin/Bacteriocin Plasmid pAD1 in Enterococcus faecalis
(Elsevier, 1994-03)
pAD1 is a hemolysin/bacteriocin plasmid originally identified in Enterococcus faecalis DS16. It encodes a mating response to a peptide sex pheromone, cAD1, secreted by recipient bacteria. Once pAD1 is acquired, production ...
Alu-PCR: Characterization of a chromosome 6-specific hybrid mapping panel and cloning of chromosome-specific markers
(Elsevier, 1992-03)
The Alu-polymerase chain reaction (Alu-PCR) was applied to selectively amplify DNA sequences from human chromosome 6 using a single primer (A1) directed to the human Alu consensus sequence. A specific amplification pattern ...
Isolation, characterization, and chromosomal mapping of mouse P450 17[alpha]-hydroxylase/C17-20 lyase
(Elsevier, 1991-05)
Cytochrome P450 17[alpha]-hydroxylase/C17-20 lyase (P45017[alpha]) catalyzes the conversion of C-21 steroids to C-19 steroids in gonads. A full-length mouse cDNA encoding P45017[alpha] was isolated from a mouse Leydig cell ...
Kidney and Retinal Defects (Krd), a Transgene-Induced Mutation with a Deletion of Mouse Chromosome 19 That Includes the Pax2 Locus
(Elsevier, 1994-09-15)
The semidominant mutation Krd (kidney and retinal defects) was identified in transgenic line Tg8052. Krd/+ mice have a high incidence of kidney defects including aplastic, hypoplastic, and cystic kidneys. Retinal defects ...