Now showing items 4211-4220 of 4365
The 70-kDa Heat Shock Protein (Hsp70) Chaperone System: Linking ATP Turnover and Complex Formation To Protein Homeostasis.
(2014)
The 70-kDa heat shock protein (Hsp70) is a molecular chaperone that binds unfolded proteins and directs them towards a number of divergent pathways, including folding, trafficking, and degradation. This delicate balance ...
Mechanism of Cytoskeleton Modification by Histone Methyltransferase SETD2
(2021)
In order for the busy and crowded cell to have a semblance of organization, it leverages a complex and dynamic network of polymers, the cytoskeleton, to provide structure and serve as molecular roads for cargo transport. ...
Interactions Between Fluorescent Molecules and Plasmonic Nanoparticles: A Super-Resolution Study
(2017)
Single-molecule super-resolution imaging techniques play an increasingly important role in studying complex fine structures, dynamics and interactions in nanoscale confined spaces. The resolution of this technique can be ...
PSM Small Peptide Toxins Form Functional Bacterial Amyloids in the Staphylococcus aureus Biofilm Matrix.
(2014)
Staphylococcus aureus is a Gram-positive opportunistic pathogen colonizing mammalian hosts. Like many bacteria, S. aureus forms multicellular aggregates called biofilms. Biofilms are surface-associated communities of ...
Development and Discovery of Novel Inhibitors of Mycobacterium tuberculosis RNA Polymerase for the Treatment of Tuberculosis
(2022)
Tuberculosis (TB) is an infectious pulmonary disease caused by the pathogen Mycobacterium tuberculosis (MTB). It is the leading cause of death from a single bacterial pathogen and second, only to COVID-19, as the deadliest ...
Retroactivity to the Output of Transcription Devices: Quantification and Insulation.
(2012)
Traditional engineering often relies on hierarchical design techniques to build com-
plex systems from simpler subsystems. This technique requires modularity, a prop-
erty that states that the input/output characteristics ...
Mass Spectrometry Based Techniques for In Vivo Neurochemical Monitoring.
(2012)
Neurotransmitter concentration in vivo reflects various behavioral and pharmacological events. Therefore, the measurement of neurochemical dynamics in live behaving animals’ brain is of crucial importance for the fundamental ...
Development of Chemical Modulators for Heat Shock Protein 70 (Hsp70): a Potential Therapeutic Target for Tauopathies.
(2012)
Tauopathies are a class of neurodegenerative disorders, which affect millions of people worldwide. These diseases are characterized by the accumulation of protein aggregates composed of abnormally modified variants of the ...
Structural Enzymology of Sulfide Oxidation by Persulfide Dioxygenase and Rhodanese
(2017)
Hydrogen sulfide (H2S) is the third eukaryotic gaseous signaling molecule and evokes a broad range of physiological effects. H2S levels are governed by the rates of its production and clearance. In eukaryotes, sulfide ...
How a Novel Zinc Finger Domain Improves Target Gene Selection by TCF in WNT/ß-Catenin Signaling.
(2014)
The Wnt/beta-catenin pathway is a highly conserved signaling pathway that plays an important role in metazoan development. T-cell factors (TCF) are transcription factors that regulate the transcription of many Wnt target ...