Now showing items 4251-4260 of 4365
Protein-Protein Interactions During Acyl Transfer In Polyketide Biosynthesis.
(2010)
Polyketide metabolites are produced by diverse bacterial taxa, including soil-dwelling bacteria, cyanobacteria, and bacterial symbionts living within insects or marine invertebrates, and are generated by decarboxylative ...
The Role of PALS1 in Mammalian Epithelial Polarity.
(2007)
Polarity is an intrinsic feature of epithelial cells, and it is reflected by the differential distribution of proteins and lipids in the apical and basolateral surfaces. The apical and basolateral membranes are separated ...
Folding and Conformational Dynamics of the Hairpin Ribozyme and the Spliceosome: Combining Computational and Experimental Analyses.
(2009)
The vital role of RNA structure and dynamics in determining biological function is increasingly appreciated throughout the life sciences. RNA-coding genes are now recognized to be far more abundant in eukaryotes than their ...
Disruption of Model Membranes by PAMAM Dendrimers and Quantitative Nanoscale Analysis of Type I Collagen.
(2010)
erionic DPPC in the gel phase. Generation 5 and 7 Poly(amidoamine) dendrimers preferentially disrupt the fluid layer. For the first time, dendrimer can be observed collecting on top of the lipid preceding removal. The ...
Identification of Steroid-Sensitive Gene-1 as a Novel JAK2 Binding Protein and the Physiological Consequences of this Interaction.
(2008)
Growth hormone (GH) is an important regulator of body growth and metabolism. GH binding to its receptor activates the receptor-associated tyrosine kinase, JAK2, which in turn, initiates multiple signaling cascades, including ...
Structural and Functional Correlations of the Thyroid Hormone Receptor.
(2010)
Thyroid hormones (THs) play essential roles in numerous critical physiological processes. The crucial functions of TH are exerted through binding to the thyroid hormone receptor (TR). TRs can specifically regulate gene ...
Characterization of Amyloid-B Interactions at the Membrane Interface: Implications for Pathogenesis. Implications for Pathogenesis.
(2009)
The 40 and 42 residue amyloid-β (Aβ) peptides are major components of the proteinaceous plaques prevalent in the Alzheimer’s disease afflicted brain and have been shown to play an important role in instigating neuronal ...
Characterization of RPE65 and RDH12, Two Enzymes Associated with Retinal Dystrophy and Retinoid Processing.
(2010)
Phototransduction in vertebrate vision is mediated by visual pigments composed of opsin apoproteins covalently attached to a light-sensitive chromophore, 11-cis retinal. Absorption of light isomerizes 11-cis retinal to ...
Characterizing HIV-1 Transactivation Response Element Dynamics that Govern Ligand Recognition: Direct Applications to Drug Discovery.
(2010)
RNAs regulate and affect numerous cellular processes, making them highly sought therapeutic targets. One mechanism to inhibit functional RNAs is to alter their structural-dynamics using small molecule binders. While structure ...
Structural and Dynamic Basis for Assembly of the HIV-1 TAR-Tat Ribonucleoprotein Complex
(2011)
The transactivation response element (TAR), located at the 5' end of the HIV-1 genome, regulates the transcription elongation step of viral RNA. The TAR stem-loop binds the HIV viral transactivator protein (Tat), which ...