Now showing items 4711-4720 of 5097
Leveraging Lewis Acids and Visible Light for Method Development and Total Synthesis
(2022)
The synthesis of natural products, pharmaceuticals, and organic materials has long driven much of the organic chemistry research conducted in both academic and industrial settings. Target directed synthesis often inspires ...
Study of Nitrite Sensors Based on Co(III)/Rh(III)-Ligand Complexes as Selective Ionophores.
(2014)
In this dissertation, fundamental and applied studies of new ionophore-based ion-selective electrodes and optodes for selective nitrite detection are reported. The new ionophore systems are shown to be useful in the ...
Understanding the Solution Phase Chemistry and Solid State Thermodynamic Behavior of Pharmaceutical Cocrystals.
(2012)
This dissertation focuses on the thermodynamic stability and solubility of pharmaceutical cocrystals. Specifically, the objectives are to; (i) investigate the influence of coformer properties such as solubility and ionization ...
Development of a Novel Class of Multifunctional Virulence-Attenuating Antibiotics.
(2013)
Resistance to traditional antibiotics arises largely because killing bacteria or halting their reproduction induces a selective pressure on mutants able to survive treatment. Virulence-attenuating antibiotics attempt to ...
Enantioselective Synthesis of Heterocycles via Palladium Catalyzed Alkene Difunctionalization Reactions.
(2015)
Enantiopure nitrogen and oxygen containing heterocycles are prominently displayed in a variety of important pharmaceuticals and biologically active products. As such accessing these scaffolds in an enantioselective and ...
Digging Deeper into the Methods of Computational Chemistry
(2020)
This dissertation applies a skeptical but hopeful analytical paradigm and the tools of linear algebra, numerical methods, and machine learning to a diversity of problems in computational chemistry. When the foundation ...
A Fluoride Migration Approach to the Rapid Synthesis of Small Oligosaccharides
(2022)
Glycosidic bonds are ubiquitous in nature and their controlled formation is crucial for energy storage, cell-to-cell communication, transmission of the innate immune system from mother to child and much more. Despite their ...
Interrogation of Dynamic Proteins to Expand the Druggable Proteome
(2021)
The human proteome is vastly complex, and our understanding of it is constantly evolving. There are roughly 20,000 protein-coding genes in the human genome, yet only about 10% of the resultant proteins are deemed “druggable” ...
Developing Tools to Evaluate Structure-Function of c-Src Kinase.
(2016)
Kinase involvement in oncogenesis is generally due to overactive mutations and thus dysregulation of those signal transduction pathways. However, c-Src is unusual, it is frequently observed to be overexpressed in cancers, ...
Studies Towards the Total Synthesis of Atropurpuran and the Arcutines
(2019)
Compounds isolated from natural sources serve as an inspiration for current drug design and development due to their broad biological activities. However, these desirable compounds are often isolated in minute quantities ...