Now showing items 1-6 of 6
Optimal dynamic treatment regime estimation using information extraction from unstructured clinical text
(Chapman and Hall/CRCWiley Periodicals, Inc., 2022-04)
The wide-scale adoption of electronic health records (EHRs) provides extensive information to support precision medicine and personalized health care. In addition to structured EHRs, we leverage free-text clinical information ...
A utility approach to individualized optimal dose selection using biomarkers
(Wiley Periodicals, Inc., 2020-03)
In many settings, including oncology, increasing the dose of treatment results in both increased efficacy and toxicity. With the increasing availability of validated biomarkers and prediction models, there is the potential ...
Probing Local Atomic Environments to Model RNA Energetics and Structure
(2020)
Ribonucleic acids (RNA) are critical components of living systems. Understanding RNA structure and its interaction with other molecules is an essential step in understanding RNA-driven processes within the cell. Experimental ...
Direct Identification and Counting of MicroRNAs in Single Cells by Transient Binding and Kinetic Fingerprinting
(2023)
Cancer is the second leading cause of mortality worldwide. Within the U.S. alone, it is estimated that 1.9 million people will be diagnosed this year and over 610,000 people are expected to perish. Despite advances in ...
Computational Methods for Understanding Dynamics in Mass Transport and Tissue Development
(2020)
Elucidating the process by which a biological system evolves and properly identifying hidden states and influential underlying factors are important for studying biological functions and origins of diseases. However, due ...
Development and Application of Numerical Methods in Biomolecular Solvation
(2021)
This work addresses the development of fast summation methods for long range particle interactions and their application to problems in biomolecular solvation, which describes the interaction of proteins or other biomolecules ...