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Flow‐aligned, single‐shot fiber diffraction using a femtosecond X‐ray free‐electron laser

dc.contributor.authorPopp, David
dc.contributor.authorLoh, N. Duane
dc.contributor.authorZorgati, Habiba
dc.contributor.authorGhoshdastider, Umesh
dc.contributor.authorLiow, Lu Ting
dc.contributor.authorIvanova, Magdalena I.
dc.contributor.authorLarsson, Mårten
dc.contributor.authorDePonte, Daniel P.
dc.contributor.authorBean, Richard
dc.contributor.authorBeyerlein, Kenneth R.
dc.contributor.authorGati, Cornelius
dc.contributor.authorOberthuer, Dominik
dc.contributor.authorArnlund, David
dc.contributor.authorBrändén, Gisela
dc.contributor.authorBerntsen, Peter
dc.contributor.authorCascio, Duilio
dc.contributor.authorChavas, Leonard M. G.
dc.contributor.authorChen, Joe P. J.
dc.contributor.authorDing, Ke
dc.contributor.authorFleckenstein, Holger
dc.contributor.authorGumprecht, Lars
dc.contributor.authorHarimoorthy, Rajiv
dc.contributor.authorMossou, Estelle
dc.contributor.authorSawaya, Michael R.
dc.contributor.authorBrewster, Aaron S.
dc.contributor.authorHattne, Johan
dc.contributor.authorSauter, Nicholas K.
dc.contributor.authorSeibert, Marvin
dc.contributor.authorSeuring, Carolin
dc.contributor.authorStellato, Francesco
dc.contributor.authorTilp, Thomas
dc.contributor.authorEisenberg, David S.
dc.contributor.authorMesserschmidt, Marc
dc.contributor.authorWilliams, Garth J.
dc.contributor.authorKoglin, Jason E.
dc.contributor.authorMakowski, Lee
dc.contributor.authorMillane, Rick P.
dc.contributor.authorForsyth, Trevor
dc.contributor.authorBoutet, Sébastien
dc.contributor.authorWhite, Thomas A.
dc.contributor.authorBarty, Anton
dc.contributor.authorChapman, Henry
dc.contributor.authorChen, Swaine L.
dc.contributor.authorLiang, Mengning
dc.contributor.authorNeutze, Richard
dc.contributor.authorRobinson, Robert C.
dc.date.accessioned2018-02-05T16:47:13Z
dc.date.available2019-01-07T18:34:38Zen
dc.date.issued2017-12
dc.identifier.citationPopp, David; Loh, N. Duane; Zorgati, Habiba; Ghoshdastider, Umesh; Liow, Lu Ting; Ivanova, Magdalena I.; Larsson, Mårten ; DePonte, Daniel P.; Bean, Richard; Beyerlein, Kenneth R.; Gati, Cornelius; Oberthuer, Dominik; Arnlund, David; Brändén, Gisela ; Berntsen, Peter; Cascio, Duilio; Chavas, Leonard M. G.; Chen, Joe P. J.; Ding, Ke; Fleckenstein, Holger; Gumprecht, Lars; Harimoorthy, Rajiv; Mossou, Estelle; Sawaya, Michael R.; Brewster, Aaron S.; Hattne, Johan; Sauter, Nicholas K.; Seibert, Marvin; Seuring, Carolin; Stellato, Francesco; Tilp, Thomas; Eisenberg, David S.; Messerschmidt, Marc; Williams, Garth J.; Koglin, Jason E.; Makowski, Lee; Millane, Rick P.; Forsyth, Trevor; Boutet, Sébastien ; White, Thomas A.; Barty, Anton; Chapman, Henry; Chen, Swaine L.; Liang, Mengning; Neutze, Richard; Robinson, Robert C. (2017). "Flow‐aligned, single‐shot fiber diffraction using a femtosecond X‐ray free‐electron laser." Cytoskeleton 74(12): 472-481.
dc.identifier.issn1949-3584
dc.identifier.issn1949-3592
dc.identifier.urihttps://hdl.handle.net/2027.42/142153
dc.description.abstractA major goal for X‐ray free‐electron laser (XFEL) based science is to elucidate structures of biological molecules without the need for crystals. Filament systems may provide some of the first single macromolecular structures elucidated by XFEL radiation, since they contain one‐dimensional translational symmetry and thereby occupy the diffraction intensity region between the extremes of crystals and single molecules. Here, we demonstrate flow alignment of as few as 100 filaments (Escherichia coli pili, F‐actin, and amyloid fibrils), which when intersected by femtosecond X‐ray pulses result in diffraction patterns similar to those obtained from classical fiber diffraction studies. We also determine that F‐actin can be flow‐aligned to a disorientation of approximately 5 degrees. Using this XFEL‐based technique, we determine that gelsolin amyloids are comprised of stacked β‐strands running perpendicular to the filament axis, and that a range of order from fibrillar to crystalline is discernable for individual α‐synuclein amyloids.
dc.publisherAcademic Press
dc.publisherWiley Periodicals, Inc.
dc.subject.otherfiber diffraction
dc.subject.otherfilament systems
dc.subject.otherXFEL
dc.titleFlow‐aligned, single‐shot fiber diffraction using a femtosecond X‐ray free‐electron laser
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/142153/1/cm21378.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/142153/2/cm21378_am.pdf
dc.identifier.doi10.1002/cm.21378
dc.identifier.sourceCytoskeleton
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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