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In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome

dc.contributor.authorBerkowitz, Bruce A.
dc.contributor.authorLenning, Jacob
dc.contributor.authorKhetarpal, Nikita
dc.contributor.authorTran, Catherine
dc.contributor.authorWu, Johnny Y.
dc.contributor.authorBerri, Ali M.
dc.contributor.authorDernay, Kristin
dc.contributor.authorHaacke, E. Mark
dc.contributor.authorShafie‐khorassani, Fatema
dc.contributor.authorPodolsky, Robert H.
dc.contributor.authorGant, John C.
dc.contributor.authorMaimaiti, Shaniya
dc.contributor.authorThibault, Olivier
dc.contributor.authorMurphy, Geoffrey G.
dc.contributor.authorBennett, Brian M.
dc.contributor.authorRoberts, Robin
dc.date.accessioned2020-03-17T18:26:35Z
dc.date.available2020-03-17T18:26:35Z
dc.date.issued2017-09
dc.identifier.citationBerkowitz, Bruce A.; Lenning, Jacob; Khetarpal, Nikita; Tran, Catherine; Wu, Johnny Y.; Berri, Ali M.; Dernay, Kristin; Haacke, E. Mark; Shafie‐khorassani, Fatema ; Podolsky, Robert H.; Gant, John C.; Maimaiti, Shaniya; Thibault, Olivier; Murphy, Geoffrey G.; Bennett, Brian M.; Roberts, Robin (2017). "In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome." The FASEB Journal 31(9): 4179-4186.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/154241
dc.description.abstractHippocampus oxidative stress is considered pathogenic in neurodegenerative diseases, such as Alzheimer disease (AD), and in neurodevelopmental disorders, such as Angelman syndrome (AS). Yet clinical benefits of antioxidant treatment for these diseases remain unclear because conventional imaging methods are unable to guide management of therapies in specific hippocampus subfields in vivo that underlie abnormal behavior. Excessive production of paramagnetic free radicals in nonhippocampus brain tissue can be measured in vivo as a greaterâ thanâ normal 1/T1 that is quenchable with antioxidant as measured by quenchâ assisted (Quest) MRI. Here, we further test this approach in phantoms, and we present proofâ ofâ concept data in models of ADâ like and AS hippocampus oxidative stress that also exhibit impaired spatial learning and memory. ADâ like models showed an abnormal gradient along the CA1 dorsalâ ventral axis of excessive free radical production as measured by Quest MRI, and redoxâ sensitive calcium dysregulation as measured by manganeseâ enhanced MRI and electrophysiology. In the AS model, abnormally high free radical levels were observed in dorsal and ventral CA1. Quest MRI is a promising in vivo paradigm for bridging brain subâ field oxidative stress and behavior in animal models and in human patients to better manage antioxidant therapy in devastating neurodegenerative and neurodevelopmental diseases.â Berkowitz, B. A., Lenning J., Khetarpal, N., Tran, C., Wu, J. Y., Berri, A. M., Dernay, K., Haacke, E. M., Shafieâ Khorassani, F., Podolsky, R. H., Gant, J. C., Maimaiti, S., Thibault, O., Murphy, G. G., Bennett, B. M., Roberts, R. In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome. FASEB J. 31, 4179â 4186 (2017). www.fasebj.orgâ Berkowitz, Bruce A., Lenning, Jacob, Khetarpal, Nikita, Tran, Catherine, Wu, Johnny Y., Berri, Ali M., Dernay, Kristin, Haacke, E. Mark, Shafieâ Khorassani, Fatema, Podolsky, Robert H., Gant, John C., Maimaiti, Shaniya, Thibault, Olivier, Murphy, Geoffrey G., Bennett, Brian M., Roberts, Robin, In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome. FASEB J. 31, 4179â 4186 (2017)
dc.publisherWiley
dc.subject.otherdorsoventral CA1
dc.subject.otherreactive oxygen species
dc.subject.otherMRI
dc.subject.otherneurodevelopment disorders
dc.subject.otherneurodegenerative disease
dc.titleIn vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154241/1/fsb2fj201700229r.pdf
dc.identifier.doi10.1096/fj.201700229R
dc.identifier.sourceThe FASEB Journal
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Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

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