Construct Validity Indicators from the ARMADA STUDY for the Tablet Computer-Based NIH Toolbox Cognition Battery
Giordani, Bruno; Goldstein, Felicia C; Rigby, Taylor; Gregoire, Allyson; Reader, Jonathan M; Fisher, Jordan; Gurecki, Sydney; Bhaumik, Arijit K; Ho, Emily; Ustsinovich, Vitali; Gershon, Richard C.; Weintraub, Sandra
2022-12
Citation
Giordani, Bruno; Goldstein, Felicia C; Rigby, Taylor; Gregoire, Allyson; Reader, Jonathan M; Fisher, Jordan; Gurecki, Sydney; Bhaumik, Arijit K; Ho, Emily; Ustsinovich, Vitali; Gershon, Richard C.; Weintraub, Sandra (2022). "Construct Validity Indicators from the ARMADA STUDY for the Tablet Computer-Based NIH Toolbox Cognition Battery." Alzheimer’s & Dementia 18: n/a-n/a.
Abstract
BackgroundThe Advancing Reliable Measurement in Alzheimer’s Disease and Cognitive Aging (ARMADA) study was designed to validate and further develop the full tablet-based NIH Toolbox Assessment of Neurological and Behavioral Function within an older, racially diverse sample. This ARMADA cohort study of the Toolbox Cognition Battery (NIHTB-CB) reports construct validity, assessed through its two components: convergent (high correlations to related constructs) and discriminant (low correlations with dissimilar constructs) validity.MethodsParticipants (age range 65–99 years, 142 aged 85+) were consensus conference-diagnosed with normal cognition (N = 367), amnestic mild cognitive impairment (N = 136), and Alzheimer’s disease (N = 68). NIHTB-CB assesses domains of Fluid Executive, including Set Shifting (Dimensional Card Sort/DCCS), Inhibitory Control and Attention, (Flanker) and Working Memory (List Sort Working Memory/LSWM); Fluid Processing Speed (Pattern Comparison/PCPS), Fluid Episodic Memory (Picture Sequence Memory/PSM) and Crystalized Language (Oral Reading/ORR, Vocabulary/TPVT). Participants were also given the National Alzheimer’s Disease Coordinating Center Unified Data Set (UDS3) cognitive measures: Memory Composite (Benson Figure and Craft Stories Delayed Recall); Executive Composite (Trail Making, Semantic Fluency), Auditory Attention (Digit Span Forward), Figure Copy (Benson), and Language (Multi-lingual Naming Test). Unadjusted, (uncorrected) standard scores were created based on the full Toolbox and UDS populations.ResultBased on the large sample size, most all correlations between NIHTB-CD and UDS3 were significant, though patterns were clear. NIHTB-CB/Fluid Executive tests had highest correlations with the related UDS3 Executive factor composite (r = 0.53-0.60), approaching threshold for a “good” designation (>0.6), and “low” designation correlations (r<0.3) for Auditory Attention. PSM correlated highest with UDS Episodic Memory (r = 0.55), and lowest with Auditory Attention (r = 0.23). PCPS was highest with the Executive Composite (r = 0.53) and lowest with Language (r = 0.26). Crystalized NIHTB-CB correlated highest with UDS Language (r = 0.41-0.50) versus ORR with Memory (r = 0.22) and TPVT with Copy (r = 0.26).ConclusionResults demonstrated that the highest correlations between NIHTB-CD and UDS3 measures were between related constructs and lowest correlations were between dissimilar constructs. Thus, convergent/discriminant expectations were supported across NIHTB-CB measures, reinforcing NIHTB-CB construct validity. Consistent results across diagnoses and other analytic approaches are also presented, supporting these findings.Publisher
Wiley Periodicals, Inc.
ISSN
1552-5260 1552-5279
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