It takes a team: A gain-of-function story of p53-R249S
dc.contributor.author | Wang, H | |
dc.contributor.author | Liao, P | |
dc.contributor.author | Zeng, SX | |
dc.contributor.author | Lu, H | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2023-12-05T20:10:37Z | |
dc.date.available | 2023-12-05T20:10:37Z | |
dc.date.issued | 2019-04-01 | |
dc.identifier.issn | 1674-2788 | |
dc.identifier.issn | 1759-4685 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/30608603 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/191688 | en |
dc.description.abstract | Gain-of-function (GOF), the most malicious oncogenic activity of a cancer-promoting protein, is well illustrated to three hotspot p53 mutations at R248, R175, and R273 with distinct molecular mechanisms. Yet, less is known about another hotspot p53 mutant, R249S (p53-R249S). p53-R249S is the sole hotspot mutation in hepatocellular carcinoma (HCC) that is highly associated with chronic hepatitis B virus (HBV) infection and dietary exposure to aflatoxin B1 (AFB1). Its GOF is suggested by the facts that this mutant is associated with earlier onset of HCC and poorer prognosis of cancer patients and that its overexpression drives HCC proliferation and tumorigenesis. By contrast, simply knocking in this mutant in normal mice did not show apparent GOF activity. Hence, the GOF activity for p53-R249S and its underlying mechanisms have been elusive until recent findings offered some new insights. This review will discuss these findings as well as their clinical significance and implications for the development of a strategy to target multiple molecules as a therapy for p53-R249S-harboring HCC. | |
dc.format.medium | ||
dc.language | eng | |
dc.publisher | Oxford University Press (OUP) | |
dc.rights | Licence for published version: Creative Commons Attribution-NonCommercial 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.subject | CDK4/cyclin D1 | |
dc.subject | FBW7a | |
dc.subject | HCC | |
dc.subject | Liver cancer | |
dc.subject | PIN1 | |
dc.subject | c-Myc | |
dc.subject | p53-R249S | |
dc.subject | Animals | |
dc.subject | Carcinogenesis | |
dc.subject | Carcinoma, Hepatocellular | |
dc.subject | Cyclin D1 | |
dc.subject | Gain of Function Mutation | |
dc.subject | Humans | |
dc.subject | Liver Neoplasms | |
dc.subject | NIMA-Interacting Peptidylprolyl Isomerase | |
dc.subject | Proto-Oncogene Proteins c-myc | |
dc.subject | Tumor Suppressor Protein p53 | |
dc.title | It takes a team: A gain-of-function story of p53-R249S | |
dc.type | Article | |
dc.identifier.pmid | 30608603 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/191688/2/It takes a team a gain-of-function story of p53-R249S.pdf | |
dc.identifier.doi | 10.1093/jmcb/mjy086 | |
dc.identifier.doi | https://dx.doi.org/10.7302/21868 | |
dc.identifier.source | Journal of Molecular Cell Biology | |
dc.description.version | Published version | |
dc.date.updated | 2023-12-05T20:10:37Z | |
dc.identifier.orcid | 0000-0002-8409-5574 | |
dc.description.filedescription | Description of It takes a team a gain-of-function story of p53-R249S.pdf : Published version | |
dc.identifier.volume | 11 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 277 | |
dc.identifier.endpage | 283 | |
dc.identifier.name-orcid | Wang, H | |
dc.identifier.name-orcid | Liao, P; 0000-0002-8409-5574 | |
dc.identifier.name-orcid | Zeng, SX | |
dc.identifier.name-orcid | Lu, H | |
dc.working.doi | 10.7302/21868 | en |
dc.owningcollname | Surgery, Department of |
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