Early intranasal medication administration in out-of-hospital cardiac arrest: a randomized simulation trial
dc.contributor.author | Dowker, SR | |
dc.contributor.author | Downey, ML | |
dc.contributor.author | Majhail, NK | |
dc.contributor.author | Scott, IG | |
dc.contributor.author | Mathisson, J | |
dc.contributor.author | Rizk, D | |
dc.contributor.author | Trumpower, B | |
dc.contributor.author | Yake, D | |
dc.contributor.author | Williams, M | |
dc.contributor.author | Coulter-Thompson, E | |
dc.contributor.author | Brent, CM | |
dc.contributor.author | Smith, Graham | |
dc.contributor.author | Swor, R | |
dc.contributor.author | Rooney, Deborah | |
dc.contributor.author | Neumar, RW | |
dc.contributor.author | Friedman, CP | |
dc.contributor.author | Cooke, JM | |
dc.contributor.author | Missel, AL | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-08-01T18:47:08Z | |
dc.date.available | 2024-08-01T18:47:08Z | |
dc.date.issued | 2024-01-21 | |
dc.identifier.issn | 2688-1152 | |
dc.identifier.issn | 2688-1152 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/38260004 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/194151 | en |
dc.description.abstract | Objective: Intranasal medications have been proposed as adjuncts to out-of-hospital cardiac arrest (OHCA) care. We sought to quantify the effects of intranasal medication administration (INMA) in OHCA workflows. Methods: We conducted separate randomized OHCA simulation trials with lay rescuers (LRs) and first responders (FRs). Participants were randomized to groups performing hands-only cardiopulmonary resuscitation (CPR)/automated external defibrillator with or without INMA during the second analysis phase. Time to compression following the second shock (CPR2) was the primary outcome and compression quality (chest compression rate (CCR) and fraction (CCF)) was the secondary outcome. We fit linear regression models adjusted for CPR training in the LR group and service years in the FR group. Results: Among LRs, INMA was associated with a significant increase in CPR2 (mean diff. 44.1 s, 95% CI: 14.9, 73.3), which persisted after adjustment (p = 0.005). We observed a significant decrease in CCR (INMA 95.1 compressions per min (cpm) vs control 104.2 cpm, mean diff. −9.1 cpm, 95% CI −16.6, −1.6) and CCF (INMA 62.4% vs control 69.8%, mean diff. −7.5%, 95% CI −12.0, −2.9). Among FRs, we found no significant CPR2 delays (mean diff. −2.1 s, 95% CI −15.9, 11.7), which persisted after adjustment (p = 0.704), or difference in quality (CCR INMA 115.5 cpm vs control 120.8 cpm, mean diff. −5.3 cpm, 95% CI −12.6, 2.0; CCF INMA 79.6% vs control 81.2% mean diff. −1.6%, 95% CI −7.4, 4.3%). Conclusions: INMA in LR resuscitation was associated with diminished resuscitation performance. INMA by FR did not impede key times or quality. | |
dc.format.medium | Electronic-eCollection | |
dc.language | eng | |
dc.publisher | Wiley | |
dc.rights | Licence for published version: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | OHCA | |
dc.subject | first responder | |
dc.subject | intranasal | |
dc.subject | lay rescuer | |
dc.subject | randomized trial | |
dc.subject | simulation | |
dc.title | Early intranasal medication administration in out-of-hospital cardiac arrest: a randomized simulation trial | |
dc.type | Article | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/194151/2/Early intranasal medication administration in out-of-hospital cardiac arrest Two randomized simulation trials.pdf | |
dc.identifier.doi | 10.1002/emp2.13100 | |
dc.identifier.doi | https://dx.doi.org/10.7302/23595 | |
dc.identifier.source | JACEP Open | |
dc.description.version | Published version | |
dc.date.updated | 2024-08-01T18:47:05Z | |
dc.identifier.orcid | 0000-0002-3280-7226 | |
dc.identifier.orcid | 0000-0003-4560-2315 | |
dc.identifier.orcid | 0000-0003-0577-2125 | |
dc.identifier.orcid | 0000-0001-9335-4294 | |
dc.identifier.orcid | 0000-0001-7942-8496 | |
dc.identifier.orcid | 0000-0003-3395-5199 | |
dc.identifier.orcid | 0000-0002-4761-7185 | |
dc.identifier.orcid | 0000-0002-9879-0519 | |
dc.description.filedescription | Description of Early intranasal medication administration in out-of-hospital cardiac arrest Two randomized simulation trials.pdf : Published version | |
dc.identifier.volume | 5 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | e13100 | |
dc.identifier.name-orcid | Dowker, SR | |
dc.identifier.name-orcid | Downey, ML | |
dc.identifier.name-orcid | Majhail, NK | |
dc.identifier.name-orcid | Scott, IG | |
dc.identifier.name-orcid | Mathisson, J | |
dc.identifier.name-orcid | Rizk, D | |
dc.identifier.name-orcid | Trumpower, B | |
dc.identifier.name-orcid | Yake, D | |
dc.identifier.name-orcid | Williams, M | |
dc.identifier.name-orcid | Coulter-Thompson, E; 0000-0002-3280-7226 | |
dc.identifier.name-orcid | Brent, CM; 0000-0003-4560-2315 | |
dc.identifier.name-orcid | Smith, Graham; 0000-0003-0577-2125 | |
dc.identifier.name-orcid | Swor, R | |
dc.identifier.name-orcid | Rooney, Deborah; 0000-0001-9335-4294 | |
dc.identifier.name-orcid | Neumar, RW; 0000-0001-7942-8496 | |
dc.identifier.name-orcid | Friedman, CP; 0000-0003-3395-5199 | |
dc.identifier.name-orcid | Cooke, JM; 0000-0002-4761-7185 | |
dc.identifier.name-orcid | Missel, AL; 0000-0002-9879-0519 | |
dc.working.doi | 10.7302/23595 | en |
dc.owningcollname | Learning Health Sciences, Department of (DLHS) |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.