Electroencephalographic assessment of the role of [delta] receptors in opioid peptide - induced seizures
dc.contributor.author | Tortella, Frank C. | en_US |
dc.contributor.author | Robles, Lydia | en_US |
dc.contributor.author | Mosberg, Henry I. | en_US |
dc.contributor.author | Holaday, John W. | en_US |
dc.date.accessioned | 2006-04-07T18:16:30Z | |
dc.date.available | 2006-04-07T18:16:30Z | |
dc.date.issued | 1984-12 | en_US |
dc.identifier.citation | Tortella, Frank C., Robles, Lydia, Mosberg, Henry I., Holaday, John W. (1984/12)."Electroencephalographic assessment of the role of [delta] receptors in opioid peptide - induced seizures." Neuropeptides 5(1-3): 213-216. <http://hdl.handle.net/2027.42/24611> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WNR-4C48C8T-9C/2/ec377db069e6f344a164334599f453fd | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/24611 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6099500&dopt=citation | en_US |
dc.description.abstract | DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for [delta] opioid receptors. Intracerebroventricular (i.c.v.) administration of each analog acutely produces a complex EEG response in rats characterized by a dose-related increase in spectral power and HVSA (peak frequency of 5.0 Hz) during behavioral stupor, and a theta driving (5.25-8.0 Hz) associated with intense behavioral arousal. These effects were antagonized by high (10 mg/kg), but not low (1.0 mg/kg), doses of naloxone. Both analogs failed to cause EEG or convulsive seizures. In contrast, i.c.v. administration of DADLE ([D-Ala2, D-Leu5]-Enkephalin), an enkephalin analog with activity at both [mu] and [delta] binding sites, caused initial nonconvulsive EEG seizures followed by HVSA (3.0 Hz); theta driving was not evident. The incidence of the seizures was dose-related and antagonized by very low doses of naloxone (0.01-1.0 mg/kg). Collectively, the inability of DPDPE and DPLPE to cause seizure activity, and the marked sensitivity of DADLE-induced EEG seizures to naloxone, suggest that [delta] receptors are not directly responsible for DADLE-induced EEG seizure activity. Furthermore, these data implicate [mu] opioid receptors as the primary sites responsible for enkephalin-induced seizures. | en_US |
dc.format.extent | 301953 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Electroencephalographic assessment of the role of [delta] receptors in opioid peptide - induced seizures | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuropharmacology Br., Division of NP, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100, USA; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Neuropharmacology Br., Division of NP, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100, USA; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Neuropharmacology Br., Division of NP, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100, USA; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Neuropharmacology Br., Division of NP, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100, USA; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 6099500 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/24611/1/0000021.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0143-4179(84)90065-9 | en_US |
dc.identifier.source | Neuropeptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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