Mechanisms of topical delivery of liposomally entrapped drugs
dc.contributor.author | Ho, Norman F. H. | en_US |
dc.contributor.author | Ganesan, Madurai G. | en_US |
dc.contributor.author | Weiner, Norman D. | en_US |
dc.contributor.author | Flynn, Gordon L. | en_US |
dc.date.accessioned | 2006-04-07T18:54:33Z | |
dc.date.available | 2006-04-07T18:54:33Z | |
dc.date.issued | 1985-11 | en_US |
dc.identifier.citation | Ho, N. F. H., Ganesan, M. G., Weiner, N. D., Flynn, G. L. (1985/11)."Mechanisms of topical delivery of liposomally entrapped drugs." Journal of Controlled Release 2(): 61-65. <http://hdl.handle.net/2027.42/25506> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T3D-47CJD54-8/2/82e557b2ecb67e68c6d56d7c76335a69 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25506 | |
dc.description.abstract | Our research on the mechanism by which liposomally entrapped solutes are transported across the skin was prompted by an investigation reported in the literature which con- cluded with meager supporting evidence that liposomes containing triamcinolone acetonide penetrated the stratum corneum intact and, thereby, increased skin absorption. To elucidate the mechanism we used glucose, hydrocortisone, progesterone and multilamellar DPPC liposomes. Experimental strategies involved: DSC determinations, in vivo permeation of hairless mouse skin by liposomes, by liposome-entrapped solutes (15:1) and by solutes in simple solution; and in vitro release kinetics of liposome-entrapped solutes.The liposomes neither penetrated the skin nor fused with the stratum corneum. Progesterone and hydrocortisone, which were intercalated in the bilayer structure, permeated the skin with ease comparable to free drug. The skin transport of the highly polar glucose entrapped in the aqueous regions of the liposome was markedly slow as compared to the free species. Physical model analysis indicated that the slow release rate of glucose out of the liposome was the rate-determining step as compared to the relatively rapid skin permeation of the free solute. For the hydrophobic progesterone and hydrocortisone, quantitative analyses suggested direct transfer of drug from the liposome to the surface phases of skin and subsequent diffusion through the tissue. Considering this mechanism and owing to increased solubility of lipophilic drugs in liposomes, more total drug may be delivered through the skin by liposomes relative to simple aqueous solution. | en_US |
dc.format.extent | 469891 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Mechanisms of topical delivery of liposomally entrapped drugs | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan., Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan., Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Drug Delivery Systems Research, The Upjohn Company, Kalamazoo, MI 49001, U.S.A. | en_US |
dc.contributor.affiliationother | Pharmaceutical Research and Development, Lederle Laboratories, Pearl River, N Y 10965, U.S.A. | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25506/1/0000047.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0168-3659(85)90033-1 | en_US |
dc.identifier.source | Journal of Controlled Release | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.