Mutagenicity in Salmonella assays of cyclohexane epoxide derivatives
dc.contributor.author | Frantz, Stephen W. | en_US |
dc.contributor.author | Van Den Eeckhout, E. | en_US |
dc.contributor.author | Sinsheimer, Joseph E. | en_US |
dc.contributor.author | Yoshihara, M. | en_US |
dc.contributor.author | Koreeda, Masato | en_US |
dc.date.accessioned | 2006-04-07T19:04:14Z | |
dc.date.available | 2006-04-07T19:04:14Z | |
dc.date.issued | 1985-06 | en_US |
dc.identifier.citation | Frantz, S. W., van den Eeckhout, E., Sinsheimer, J. E., Yoshihara, M., Koreeda, M. (1985/06)."Mutagenicity in Salmonella assays of cyclohexane epoxide derivatives." Toxicology Letters 25(3): 265-271. <http://hdl.handle.net/2027.42/25651> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TCR-477Y2NM-22M/2/709c63009e36e0d21eeb659100f2c6cc | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25651 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4012804&dopt=citation | en_US |
dc.description.abstract | 15 Cyclohexane epoxide derivatives were synthesized and compared for direct mutagenicity an bacterial toxicity using Salmonella typhimurium strain TA100 in the liquid suspension and spot-test version of the Ames procedure. While no general correlations could be established for position and stereochemistry of the hydroxylated derivatives, an increase in mutagenicity was noted for the presence of electron-withdrawing groups and unsaturation in conjugation with the oxirane groups. | en_US |
dc.format.extent | 435694 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Mutagenicity in Salmonella assays of cyclohexane epoxide derivatives | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 4012804 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25651/1/0000203.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-4274(85)90206-1 | en_US |
dc.identifier.source | Toxicology Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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