Removal of the anticoagulant activities of the low molecular weight heparin fractions and fragments with flavobacterial heparinase
dc.contributor.author | Yang, Victor C. | en_US |
dc.contributor.author | Bernstein, Howard | en_US |
dc.contributor.author | Cooney, Charles L. | en_US |
dc.contributor.author | Kadam, Jill C. | en_US |
dc.contributor.author | Langer, Robert S. | en_US |
dc.date.accessioned | 2006-04-07T19:23:25Z | |
dc.date.available | 2006-04-07T19:23:25Z | |
dc.date.issued | 1986-12-01 | en_US |
dc.identifier.citation | Yang, Victor C., Bernstein, Howard, Cooney, Charles L., Kadam, Jill C., Langer, Robert (1986/12/01)."Removal of the anticoagulant activities of the low molecular weight heparin fractions and fragments with flavobacterial heparinase." Thrombosis Research 44(5): 599-610. <http://hdl.handle.net/2027.42/25962> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1C-4C2RTHW-B9/2/f5800760b074a77d030d68e7f13bc1be | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/25962 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3810562&dopt=citation | en_US |
dc.description.abstract | Recently, the development of low molecular weight heparin fractions and fragments. (LMHF) as potential anti-thrombotic agents has gained increased attention. However, the lack of antagonists to neutralize the anti-coagulant effects of these drugs may seriously exclude them from possible uses in extracorporeal therapy. This is mainly because of the concern that the high dosage of the drugs employed in extracorporeal therapy could lead to serious bleeding risks. Our earlier work has demonstrated that immobilized heparinase can remove polydis-perse heparin both and . To examine whether such a system may be used as a novel approach to neutralize the anticoagulant effects of LMHF, different LMMF were tested using heparinase. data showed that both the APTT and anti-FXa activities of the LMHF including Kabi 2165, PK 10169, CY 216 and CY 222 were nearly completely eliminated by heparinase in less than 20 min. This study suggests that an immobilized heparinase system may be an useful element for the acceptance of the LMHF for their use in extracorporeal, therapy. | en_US |
dc.format.extent | 991537 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Removal of the anticoagulant activities of the low molecular weight heparin fractions and fragments with flavobacterial heparinase | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Current address: College of Pharmacy, The University of Michigan, Ann Arbor, Michigan 48109, USA: Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA | en_US |
dc.contributor.affiliationother | Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA: Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA | en_US |
dc.contributor.affiliationother | Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA: Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA | en_US |
dc.contributor.affiliationother | Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA | en_US |
dc.contributor.affiliationother | Department of Surgery, Children's Hospital Medical Center, Boston, Massachusetts 02115, USA: Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA | en_US |
dc.identifier.pmid | 3810562 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/25962/1/0000028.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0049-3848(86)90162-3 | en_US |
dc.identifier.source | Thrombosis Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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