Opioid [delta]-receptor involvement in supraspinal and spinal antinociception in mice
dc.contributor.author | Heyman, Julius S. | en_US |
dc.contributor.author | Mulvaney, Sheila A. | en_US |
dc.contributor.author | Mosberg, Henry I. | en_US |
dc.contributor.author | Porreca, Frank | en_US |
dc.date.accessioned | 2006-04-07T19:48:36Z | |
dc.date.available | 2006-04-07T19:48:36Z | |
dc.date.issued | 1987-09-08 | en_US |
dc.identifier.citation | Heyman, Julius S., Mulvaney, Sheila A., Mosberg, Henry I., Porreca, Frank (1987/09/08)."Opioid [delta]-receptor involvement in supraspinal and spinal antinociception in mice." Brain Research 420(1): 100-108. <http://hdl.handle.net/2027.42/26577> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-4836162-28K/2/aeea0eaf588160e5830161be6dc6c3a0 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26577 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2823970&dopt=citation | en_US |
dc.description.abstract | The possibility that the opioid [delta]-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective [mu]- and [delta]-agonists and -antagonists. Antinociceptive dose-response curves were constructed for [mu] ([-Ala2, NMePhe4, Gly-ol]enkephalin, DAGO; morphine) and [delta] ([-Pen2,-Pen5]enkephalin, DPDPE)-agonist in the absence, and in the presence of the [mu] non-surmountable antagonist, [beta]-funaltrexamine ([beta]-FNA) or the [delta]-antagonist ICI 174,864 (N,N-diallyl-Tyr-Aib-Aib-Phe-Leu- OH, where Aib is [alpha]-amino-isobutyric acid). Agonists and ICI 174,864 were given alone or in the same intracerebroventicular (i.c.v.) or intrathecal (i.th.) injection to mice 20 min prior to testing in the warm-water (55 [deg]C) tail-withdrawal test (+10 min for i.th. DPDPE); [beta]-FNA was given as a single i.c.v. or i.th. pretreatment dose (20 and 0.01 nM, respectively) 4 hr with [beta]-FNA resulted in a rightward displacement of the DAGO and morphine antinociceptive dose-response lines, but failed to displace the i.c.v. DPDPE curve. Similarly, i.th. pretreatment with [beta]-FNA displaced the i.th. morphine dose-response curve to the right without affecting the i.th. DPDPE antinociceptive dose-response line. ICI 174,864 (1 and 3 [mu]g) produced a dose-related antagonism of i.c.v. or i.th. DPDPE, but did not alter the antinociceptive effects of DAGO or morphine given by the same routes. Co-administration of ICI 174 864 ([mu]g) i.c.v. morphine in [beta]-FNA pretreated (but not control) mkce resulted in a further rightward displacement of the morphine dose-response line. The effective antagonism of DPDPE but not morphine or DAGO antinociception by ICI 174,864, together with the effectiveness of [beta]-FNA against morphine and DAGO but not DPDPE antinociception, provide strong and direct evidence for the involvement of cerebral and spinal [delta]-receptors in the mediation of antinociception in tests where heat is employed as the noxious stimulus. Additionally, the effectiveness of ICI 174,864 against morphine in [beta]-FNA pretreated (but not control) mice demonstrates a [delta]-effect of morphine, in vivo. | en_US |
dc.format.extent | 712961 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Opioid [delta]-receptor involvement in supraspinal and spinal antinociception in mice | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, U.S.A. | en_US |
dc.identifier.pmid | 2823970 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26577/1/0000116.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(87)90244-7 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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