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Inhibition of herpes simplex virus DNA replication by ara-tubercidin

dc.contributor.authorTurk, Steven R.en_US
dc.contributor.authorCook, P. Danen_US
dc.contributor.authorReinke, C. Michaelen_US
dc.contributor.authorDrach, John C.en_US
dc.date.accessioned2006-04-07T19:48:49Z
dc.date.available2006-04-07T19:48:49Z
dc.date.issued1987-09en_US
dc.identifier.citationTurk, Steven R., Dan Cook, P., Reinke, C. Michael, Drach, John C. (1987/09)."Inhibition of herpes simplex virus DNA replication by ara-tubercidin." Antiviral Research 8(2): 97-102. <http://hdl.handle.net/2027.42/26583>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T2H-4D2844Y-4/2/b382a03f196794943a89682b24f175ffen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/26583
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2830847&dopt=citationen_US
dc.description.abstractPreliminary studies of the biochemical basis for the antiviral activity of the pyrrolo[2,3-d]pyrimidine nucleoside ara-tubercidin were conducted. Herpes simplex virus DNA synthesis was 3-fold more sensitive to inhibition by ara-tubercidin than was cellular DNA synthesis. Partially purified herpes DNA polymerases were more sensitive to inhibition by ara-tubercidin 5'-triphosphate than were cellular polymerases [alpha] and [beta]. Inhibition of viral DNA polymerase was competitive with dATP and noncompetitive with dTTP. The results suggest that the viral DNA polymerase plays a significant role in the antiviral activity of ara-tubercidin.en_US
dc.format.extent446052 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleInhibition of herpes simplex virus DNA replication by ara-tubercidinen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Oral Biology, School of Dentistry, The University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationumDepartment of Oral Biology, School of Dentistry, The University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationumDepartment of Oral Biology, School of Dentistry, The University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationotherWarner-Lambert/Parke-Davis, Ann Arbor, Michigan, U.S.A.en_US
dc.identifier.pmid2830847en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/26583/1/0000124.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0166-3542(87)90080-5en_US
dc.identifier.sourceAntiviral Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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