Inhibition of herpes simplex virus DNA replication by ara-tubercidin
dc.contributor.author | Turk, Steven R. | en_US |
dc.contributor.author | Cook, P. Dan | en_US |
dc.contributor.author | Reinke, C. Michael | en_US |
dc.contributor.author | Drach, John C. | en_US |
dc.date.accessioned | 2006-04-07T19:48:49Z | |
dc.date.available | 2006-04-07T19:48:49Z | |
dc.date.issued | 1987-09 | en_US |
dc.identifier.citation | Turk, Steven R., Dan Cook, P., Reinke, C. Michael, Drach, John C. (1987/09)."Inhibition of herpes simplex virus DNA replication by ara-tubercidin." Antiviral Research 8(2): 97-102. <http://hdl.handle.net/2027.42/26583> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T2H-4D2844Y-4/2/b382a03f196794943a89682b24f175ff | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26583 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2830847&dopt=citation | en_US |
dc.description.abstract | Preliminary studies of the biochemical basis for the antiviral activity of the pyrrolo[2,3-d]pyrimidine nucleoside ara-tubercidin were conducted. Herpes simplex virus DNA synthesis was 3-fold more sensitive to inhibition by ara-tubercidin than was cellular DNA synthesis. Partially purified herpes DNA polymerases were more sensitive to inhibition by ara-tubercidin 5'-triphosphate than were cellular polymerases [alpha] and [beta]. Inhibition of viral DNA polymerase was competitive with dATP and noncompetitive with dTTP. The results suggest that the viral DNA polymerase plays a significant role in the antiviral activity of ara-tubercidin. | en_US |
dc.format.extent | 446052 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Inhibition of herpes simplex virus DNA replication by ara-tubercidin | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Oral Biology, School of Dentistry, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Oral Biology, School of Dentistry, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Oral Biology, School of Dentistry, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationother | Warner-Lambert/Parke-Davis, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 2830847 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26583/1/0000124.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0166-3542(87)90080-5 | en_US |
dc.identifier.source | Antiviral Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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