Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes
dc.contributor.author | Becker, Michael A. | en_US |
dc.contributor.author | Heidler, Steven A. | en_US |
dc.contributor.author | Bell, Graeme I. | en_US |
dc.contributor.author | Seino, Susumu | en_US |
dc.contributor.author | Le Beau, Michelle M. | en_US |
dc.contributor.author | Westbrook, Carol A. | en_US |
dc.contributor.author | Neuman, Wilma | en_US |
dc.contributor.author | Shapiro, Larry J. | en_US |
dc.contributor.author | Mohandas, T. K. | en_US |
dc.contributor.author | Roessler, Blake J. | en_US |
dc.contributor.author | Palella, Thomas D. | en_US |
dc.date.accessioned | 2006-04-10T13:34:41Z | |
dc.date.available | 2006-04-10T13:34:41Z | |
dc.date.issued | 1990-11 | en_US |
dc.identifier.citation | Becker, Michael A., Heidler, Steven A., Bell, Graeme I., Seino, Susumu, Le Beau, Michelle M., Westbrook, Carol A., Neuman, Wilma, Shapiro, Larry J., Mohandas, T. K., Roessler, Blake J., Palella, Thomas D. (1990/11)."Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes." Genomics 8(3): 555-561. <http://hdl.handle.net/2027.42/28336> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-4DXK9Y3-M/2/e8e0f420dc6dc3bf7c034021d83f4415 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28336 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1962753&dopt=citation | en_US |
dc.description.abstract | Cloned cDNAs representing the entire, homologous (80%) translated sequences of human phosphoribosylpyrophosphate synthetase (PRS) 1 and PRS 2 cDNAs were utilized as probes to localize the corresponding human PRPS1 and PRPS2 genes, previously reported to be X chromosome linked. PRPS1 and PRPS2 loci mapped to the intervals Xq22-q24 and Xp22.2-p22.3, respectively, using a combination of in situ chromosomal hybridization and human x rodent somatic cell panel genomic DNA hybridization analyses. A PRPS1-related gene or pseudogene (PRPS1L2) was also identified using in situ chromosomal hybridization at 9q33-q34. Human HPRT and PRPS1 loci are not closely linked. Despite marked cDNA and deduced amino acid sequence homology, human PRS 1 and PRS 2 isoforms are encoded by genes widely separated on the X chromosome. | en_US |
dc.format.extent | 1015774 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 49104, USA; Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA. | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA | en_US |
dc.contributor.affiliationother | Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA | en_US |
dc.contributor.affiliationother | Department of Biological Chemistry, Harbor-UCLA Medical Center, Torrance, California 90509, USA; Howard Hughes Medical Institute, Harbor-UCLA Medical Center, Torrance, California 90509, USA; Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA. | en_US |
dc.contributor.affiliationother | Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California 90509, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California 90509, USA | en_US |
dc.identifier.pmid | 1962753 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28336/1/0000095.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0888-7543(90)90043-T | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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