Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase C [gamma]1
dc.contributor.author | Ohmichi, Masahide | en_US |
dc.contributor.author | Decker, Stuart J. | en_US |
dc.contributor.author | Pang, Long | en_US |
dc.contributor.author | Saltiel, Alan R. | en_US |
dc.date.accessioned | 2006-04-10T14:36:46Z | |
dc.date.available | 2006-04-10T14:36:46Z | |
dc.date.issued | 1991-08-30 | en_US |
dc.identifier.citation | Ohmichi, Masahide, Decker, Stuart J., Pang, Long, Saltiel, Alan R. (1991/08/30)."Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase C [gamma]1." Biochemical and Biophysical Research Communications 179(1): 217-223. <http://hdl.handle.net/2027.42/29169> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DXRY44-1YV/2/88e4748fc897eef4073d0c77dd4c018a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29169 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1715690&dopt=citation | en_US |
dc.description.abstract | The cellular actions of nerve growth factor (NGF) involve regulation of protein phosphorylation. In PC-12 pheochromocytoma cells, exposure of [125I]NGF followed by crosslinking indicates that the ligand binds to two discreet receptors, the previously described 75 kd protein, as well as the trk proto-oncogene product pp140c-trk. Competition experiments reveal that of the two, pp140c-trk binds to NGF with higher affinity. Following exposure to NGF, pp140c-trk undergoes a rapid autophosphorylation on tyrosine residues, and concomitantly phosphorylates and associates with phospholipase C[gamma]1 (PLC[gamma]1), through interaction with its src homology domains. The binding of NGF to pp140c-trk with high affinity, the NGF-dependent activation of its tyrosine kinase activity and the specific association with the effector molecule, PLC[gamma]1, suggests that this is the biologically relevant signaling receptor for NGF. | en_US |
dc.format.extent | 2008620 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase C [gamma]1 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Signal Transduction, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA; Department of Physiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Signal Transduction, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA; Department of Microbiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Signal Transduction, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA; Department of Physiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Department of Signal Transduction, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA | en_US |
dc.identifier.pmid | 1715690 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29169/1/0000215.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(91)91357-I | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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