Life Sciences Institute (LSI)

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The Life Sciences Institute at the University of Michigan achieves excellence in biomedical research by bringing together the world’s leading scientists from a variety of life science disciplines to accelerate breakthroughs and discoveries that will improve human health. With close to 400 scientific staff members, the LSI is exploiting the power of a collaborative and interdisciplinary approach to biomedical research in an open-laboratory facility.

Recent Deposits

Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases

Chigumba, DN; Mydy, LS; de Waal, F; Li, W; Shafiq, K; Wotring, JW; Mohamed, OG; Mladenovic, T; Tripathi, A; Sexton, JZ; Kautsar, S; Medema, MH; Kersten, RD (Springer Nature, 2022-01-01)

(8MB)
Migrating pyramidal neurons require DSCAM to bypass the border of the developing cortical plate.

Yang, T; Veling, MW; Zhao, XF; Prin, NP; Zhu, L; Hergenreder, T; Liu, H; Liu, L; Rane, Z; Savelieff, MG; Fuerst, PG; Li, Q; Kwan, KY; Giger, RJ; Wang, Y; Ye, B (Society for Neuroscience, 2022-01-06)

(6.3MB)
Ross MAP Team: UM Center for Discovery of New Medicines (CDNM) Final Report

Camalo, Patrick; Hashimoto, Ichiro; Kerppola, Marianna; Koul, Neha (2015-04-29)

(2MB)
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

O'Leary, John C III; Li, Qingyou; Marinec, Paul; Blair, Laura J; Congdon, Erin E; Johnson, Amelia G; Jinwal, Umesh K; Koren, John III; Jones, Jeffrey R; Kraft, Clara; Peters, Melinda; Abisambra, Jose F; Duff, Karen E; Weeber, Edwin J; Gestwicki, Jason E.; Dickey, Chad A (2010-11-01)

(51.3KB) (2.9MB) (764.7KB)
Multiple roles of the cytoskeleton in autophagy

Monastyrska, Iryna; Rieter, Ester; Klionsky, Daniel J.; Reggiori, Fulvio (Blackwell Publishing Ltd, 2009-08)

(932.4KB)
STATISTICAL TESTS FOR TAXONOMIC DISTINCTIVENESS FROM OBSERVATIONS OF MONOPHYLY

Rosenberg, Noah A. (Blackwell Publishing Inc, 2007-02)

(148.7KB)
Bone marrow cell trafficking following intravenous administration

Cui, Jisong; Wahl, Richard L.; Shen, Tingliang; Fisher, Susan J.; Recker, Elizabeth; Ginsburg, David W.; Long, Michael W. (Blackwell Science Ltd, 1999-12)

(309KB)
Vac8p, an Armadillo Repeat Protein, Coordinates Vacuole Inheritance With Multiple Vacuolar Processes

Tang, Fusheng; Peng, Yutian; Nau, Johnathan J.; Kauffman, Emily J.; Weisman, Lois S. (Blackwell Publishing Ltd, 2006-10)

(859.6KB)
The structural view of bacterial translocation-specific chaperone SecB: implications for function

Zhou, Jiahai; Xu, Zhaohui (Blackwell Science Ltd, 2005-10)

(724.9KB)
Insulin Signaling in Microdomains of the Plasma Membrane

Saltiel, Alan R.; Pessin, Jeffrey E. (Munksgaard International PublishersBlackwell Publishing Ltd, 2003-11)

(243.4KB)
Approaching the Molecular Mechanism of Autophagy

Klionsky, Daniel J.; Stromhaug, Per E. (Munksgaard International PublishersBlackwell Publishing Ltd, 2001-08)

(264.3KB)
Cargo Selectivity of the ERGIC-53/MCFD2 Transport Receptor Complex

Nyfeler, Beat; Zhang, Bin; Ginsburg, David W.; Kaufman, Randal J.; Hauri, Hans-Peter (Blackwell Publishing Ltd, 2006-11)

(1.1MB)
Inhibition of binding of phospholipase CΓ1 SH2 domains to phosphorylated epidermal growth factor receptor by phosphorylated peptides

McNamara, Dennis J.; Dobrusin, Ellen M.; Zhu, Guochang; Decker, Stuart J.; Saltiel, Alan R. (Blackwell Publishing Ltd, 1993-09)

(894.4KB)
Palmitoylation Plays a Role in Targeting Vac8p to Specific Membrane Subdomains

Peng, Yutian; Tang, Fusheng; Weisman, Lois S. (Blackwell Publishing Ltd, 2006-10)

(838KB)
Structure–activity Relationships of Amyloid Beta-aggregation Inhibitors Based on Curcumin: Influence of Linker Length and Flexibility

Reinke, Ashley A.; Gestwicki, Jason E. (Blackwell Publishing Ltd, 2007-09)

(579.9KB)
Chemical Biology: Learning through Case Studies . By Herbert Waldmann and Petra Janning .

Gestwicki, Jason E. (WILEY-VCH Verlag, 2009-10-12)

(88.7KB)
Replication of genetic associations as pseudoreplication due to shared genealogy

Rosenberg, Noah A.; Van Liere, Jenna M. (Wiley Subscription Services, Inc., A Wiley Company, 2009-09)

(495.6KB)
hChAT: A Tool for the Chemoenzymatic Generation of Potential Acetyl/Butyrylcholinesterase Inhibitors

Green, Keith D.; Fridman, Micha; Garneau-Tsodikova, Sylvie (WILEY-VCH Verlag, 2009-09-04)

(212.7KB)
Algorithms for Selecting Informative Marker Panels for Population Assignment

Rosenberg, Noah A. (Mary Ann Liebert, Inc., publishers, 2005-11-01)

(648.9KB)
The Many Flavors of Hyperhomocyst(e)inemia: Insights from Transgenic and Inhibitor-Based Mouse Models of Disrupted One-Carbon Metabolism

Elmore, C. Lee; Matthews, Rowena Green (2009-07-10)

(222.8KB)