Lindane may enhance nocturnal pineal N-acetyltransferase activity via [beta]-adrenergic receptors
dc.contributor.author | Attia, A. M. | en_US |
dc.contributor.author | Richardson, B. A. | en_US |
dc.contributor.author | Rodriguez, C. | en_US |
dc.contributor.author | Mostafa, M. H. | en_US |
dc.contributor.author | Soliman, S. A. | en_US |
dc.contributor.author | El-Sebae, A. H. | en_US |
dc.contributor.author | Reiter, R. J. | en_US |
dc.date.accessioned | 2006-04-10T14:38:58Z | |
dc.date.available | 2006-04-10T14:38:58Z | |
dc.date.issued | 1991-07-19 | en_US |
dc.identifier.citation | Attia, A. M., Richardson, B. A., Rodriguez, C., Mostafa, M. H., Soliman, S. A., El-Sebae, A. H., Reiter, R. J. (1991/07/19)."Lindane may enhance nocturnal pineal N-acetyltransferase activity via [beta]-adrenergic receptors." Brain Research 554(1-2): 253-256. <http://hdl.handle.net/2027.42/29221> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-484B6GF-3HF/2/61fa5b0e4b7a7204589af3fa190fb461 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29221 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1718548&dopt=citation | en_US |
dc.description.abstract | Lindane, a chlorinated hydrocarbon pesticide, was previously shown to enhance the nighttime rise in pineal N-acetyltransferase (NAT) activity and melatonin as well as serum melatonin levels. The purpose of the present study was to test whether lindane acts on the pineal gland by means of a [beta]-adrenergic receptor mechanism. Whereas lindane (total dose 17.8 mg/kg b.wt. over 6 days) by itself significantly augmented the nocturnal levels of pineal NAT activity in otherwise untreated rats, the pesticide was ineffective in reference to this enzyme when it was given in conjunction with the [beta]-adrenergic receptor antagonist propranolol (20 mg/kg b.wt., one hour before lights off). The augmentation of NAT activity by lindane also caused significant reductions in pineal serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA); again, both these responses were blocked by propranolol treatment. Neither pineal 5-hydroxytryptophan nor pineal or serum melatonin levels were significantly changed as a result of either lindane or propranolol treatment. The results are consistent with the idea that lindane influences pineal 5-HT metabolism either at the level of the [beta]-adrenergic receptor or via the sympathetic innervation to the pineal gland. | en_US |
dc.format.extent | 413459 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Lindane may enhance nocturnal pineal N-acetyltransferase activity via [beta]-adrenergic receptors | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biology, University of Michigan-Flint, Flint, MI 48502, U.S.A.; Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284-7762, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284-7762, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284-7762, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Environmental Science, Institute of Graduate Studies and Research, Alexandria, Egypt | en_US |
dc.contributor.affiliationother | Department of Environmental Science, Institute of Graduate Studies and Research, Alexandria, Egypt | en_US |
dc.contributor.affiliationother | Department of Pesticide Chemistry, Faculty of Agriculture, University of Alexandria, Alexandria, Egypt | en_US |
dc.contributor.affiliationother | Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284-7762, U.S.A. | en_US |
dc.identifier.pmid | 1718548 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29221/1/0000276.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(91)90197-4 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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