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Phenytoin crystal growth rates in the presence of phosphate and chloride ions

dc.contributor.authorZipp, Gail L.en_US
dc.contributor.authorRodriguez-Hornedo, Nairen_US
dc.date.accessioned2006-04-10T15:05:53Z
dc.date.available2006-04-10T15:05:53Z
dc.date.issued1992-09en_US
dc.identifier.citationZipp, G. L., Rodriguez-Hornedo, N. (1992/09)."Phenytoin crystal growth rates in the presence of phosphate and chloride ions." Journal of Crystal Growth 123(1-2): 247-254. <http://hdl.handle.net/2027.42/29867>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TJ6-46D6V96-141/2/1bc6c5dd9ab9a32eb365c92705591d08en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29867
dc.description.abstractPhenytoin crystal growth kinetics have been measured as a function of supersaturation in pH 2.2 phosphoric acid and pH 2.2 hydrochloric acid solutions. Two different methods were used for the kinetic analysis. The first involved a zone-sensing device which provided an analysis of the distribution of crystals in a batch crystallizer. Crystal growth rates were calculated from the increase in the size of the distribution with time. In the second method, growth rates were evaluated from the change in size with time of individual crystals observed under an inverted microscope. The results from each method compare favorably. The use of both techniques provides an excellent opportunity to exploit the strengths of each: an average growth rate from a population of crystals from batch crystallization and insight into the effect of growth on the morphology of the crystals from the individual crystal measurements.en_US
dc.format.extent634815 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titlePhenytoin crystal growth rates in the presence of phosphate and chloride ionsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbsecondlevelMathematicsen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan 48109-1065, USAen_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan 48109-1065, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29867/1/0000215.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0022-0248(92)90030-Men_US
dc.identifier.sourceJournal of Crystal Growthen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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