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The mechanism of phenytoin crystal growth
dc.contributor.authorZipp, Gail L.en_US
dc.contributor.authorRodriguez-Hornedo, Nairen_US
dc.date.accessioned2006-04-10T15:38:07Z
dc.date.available2006-04-10T15:38:07Z
dc.date.issued1993-08-31en_US
dc.identifier.citationZipp, Gail L., Rodriguez-Hornedo, Nair (1993/08/31)."The mechanism of phenytoin crystal growth." International Journal of Pharmaceutics 98(1-3): 189-201. <http://hdl.handle.net/2027.42/30628>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T7W-474YHR7-C9/2/72dec6dde802e98bd6417672827656e1en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30628
dc.description.abstractPhenytoin crystal growth kinetics have been measured as a function of pH, supersaturation and temperature in phosphate buffer. Incorporation of growth units into the crystal lattice was not influenced by diffusion from the bulk to the solid surface. Thus, the rate limiting step for phenytoin growth is surface integration. Phenytoin crystal growth is via a screw-dislocation mechanism; this mechanism explains the observed dependence of growth rate on supersaturation and the increase in growth rate with pH.en_US
dc.format.extent1064253 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe mechanism of phenytoin crystal growthen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, MI 48109-1065, USAen_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, MI 48109-1065, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30628/1/0000269.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0378-5173(93)90056-Len_US
dc.identifier.sourceInternational Journal of Pharmaceuticsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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