Viscoelasticity of cellulose polymers and mucociliary transport on frog palates
dc.contributor.author | Lin, Shun Y. | en_US |
dc.contributor.author | Amidon, Gordon L. | en_US |
dc.contributor.author | Weiner, Norman D. | en_US |
dc.contributor.author | Goldberg, Arthur H. | en_US |
dc.date.accessioned | 2006-04-10T15:42:28Z | |
dc.date.available | 2006-04-10T15:42:28Z | |
dc.date.issued | 1993-06-30 | en_US |
dc.identifier.citation | Lin, Shun Y., Amidon, Gordon L., Weiner, Normal D., Goldberg, Arthur H. (1993/06/30)."Viscoelasticity of cellulose polymers and mucociliary transport on frog palates." International Journal of Pharmaceutics 95(1-3): 57-65. <http://hdl.handle.net/2027.42/30730> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T7W-474XK90-4Y/2/ccaf073a721f12e23359f18a3f2557b6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30730 | |
dc.description.abstract | The viscoelastic propertied of model polymer, hydroxypropylmethylcellulose (HPMC), in ternary solvent mixtures and the variation of viscoelastic properties under dilution with water were investigated. HPMC was dispersed in mixtures of glycerol formal (GF) or ethyl alcohol, propylene glycol (PG), and water. Each polymeric sample was oscillated at different frequencies with fixed stress amplitude and the changes in elastic modulus, viscous modulus, and apparent viscosity were measured at 30[deg]C. The moisture absorption rate of HPMC in PG:GF solvent mixtures in a 94% relative humidified environment was also studied. A linear relationship between the elastic modulus or viscous modulus and polymer concentration was observed for the HPMC samples. The relative mucociliary transport rate tested on the non-depleted frog palate model revealed a curvilinear correlation with the loss tangent (a ratio of the viscous modulus to the elastic modulus) of the polymeric solution. Using GF as a solvent for HPMC resulted in a formation of a rigid gel with the highest elastic modulus and viscous modulus among solvents selected. A higher affinity for water was found for HPMC in the PG:GF 90:10 mixture compared with HPMC in the PG:GF 70:30 mixture. However, the elastic modulus and viscous modulus were much higher for HPMC in the PG:GF 70:30 mixture. | en_US |
dc.format.extent | 709903 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Viscoelasticity of cellulose polymers and mucociliary transport on frog palates | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109-1065, USA | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109-1065, USA | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109-1065, USA | en_US |
dc.contributor.affiliationother | Rugby-Darby Group Companies, Inc., Rockville Centre, NY 11570, USA | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30730/1/0000379.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-5173(93)90390-2 | en_US |
dc.identifier.source | International Journal of Pharmaceutics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.