Aging and eliciting agents: Effect on murine peritoneal macrophage monokine bioactivity
dc.contributor.author | Chen, Yifang | en_US |
dc.contributor.author | Bradley, Suzanne F. | en_US |
dc.date.accessioned | 2006-04-10T15:51:47Z | |
dc.date.available | 2006-04-10T15:51:47Z | |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Chen, Yifang, Bradley, Suzanne F. (1993)."Aging and eliciting agents: Effect on murine peritoneal macrophage monokine bioactivity." Experimental Gerontology 28(2): 145-159. <http://hdl.handle.net/2027.42/30935> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T6J-47RJ08P-31/2/6e64133e19d16d1e63071b7685580894 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30935 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8325351&dopt=citation | en_US |
dc.description.abstract | Decreased responsiveness of the aged to infection may be associated with a decline in monokine production. Prior studies in macrophages have used different eliciting agents, and results have varied. We assessed the effect of age on interleukin-1 (IL-1), tumor necrosis factor (TNF), and interleukin-6 (IL-6) in unelicited, thioglycollate (TG)-elicited, and complete Freund's adjuvant (CFA)-elicited peritoneal macrophages. Resident macrophages or CFA-elicited macrophages from middle aged or aged mice produced significantly less monokine bioactivity than resident or CFA-elicited macrophages from young mice. Monokine bioactivity from TG-elicited macrophages from aged and middle aged mice was significantly increased when compared with macrophages of young mice. Eliciting agents may alter macrophage populations and interactions with other cells leading to changes in monokine bioactivity with aging. | en_US |
dc.format.extent | 953192 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Aging and eliciting agents: Effect on murine peritoneal macrophage monokine bioactivity | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Veterans Affairs Medical Center, 2215 Fuller Road, Ann Arbor, Michigan 48105, USA; Divisions of Geriatric Medicine and Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, 2215 Fuller Road, Ann Arbor, Michigan 48105, USA. | en_US |
dc.contributor.affiliationum | Divisions of Geriatric Medicine and Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, 2215 Fuller Road, Ann Arbor, Michigan 48105, USA; Department of Veterans Affairs Medical Center, 2215 Fuller Road, Ann Arbor, Michigan 48105, USA. | en_US |
dc.identifier.pmid | 8325351 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30935/1/0000605.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0531-5565(93)90004-W | en_US |
dc.identifier.source | Experimental Gerontology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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