Cobalamin-dependent methionine synthase: the structure of a methylcobalamin-binding fragment and implications for other B12-dependent enzymes
dc.contributor.author | Drennan, Catherine Luschinsky | en_US |
dc.contributor.author | Matthews, Rowena Green | en_US |
dc.contributor.author | Ludwig, Martha L. | en_US |
dc.date.accessioned | 2006-04-10T18:29:54Z | |
dc.date.available | 2006-04-10T18:29:54Z | |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Drennan, Catherine Luschinsky, Matthews, Rowena G., Ludwig, Martha L. (1994)."Cobalamin-dependent methionine synthase: the structure of a methylcobalamin-binding fragment and implications for other B12-dependent enzymes." Current Opinion in Structural Biology 4(6): 919-929. <http://hdl.handle.net/2027.42/31943> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6VS6-4BSM8VP-M/2/6051714523b398ac3ab902fa02d70cbf | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31943 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7712296&dopt=citation | en_US |
dc.description.abstract | Cobalamin-dependent methionine synthase is a large enzyme composed of structurally and functionally distinct regions. Recent studies have begun to define the roles of several regions of the protein. In particular, the structure of a 27 kDa cobalamin-binding fragment of the enzyme from Escherichia coli has been determined by X-ray crystallography, and has revealed the motifs and interactions responsible for recognition of the cofactor. The amino acid sequences of several adenosylcobalamin-dependent enzymes, the methylmalonyl coenzyme A mutases and glutamate mutases, show homology with the cobalamin-binding region of methionine synthase and retain conserved residues that are determinants for the binding of the prosthetic group, suggesting that these mutases and methionine synthase share common three-dimensional structures. | en_US |
dc.format.extent | 1224630 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Cobalamin-dependent methionine synthase: the structure of a methylcobalamin-binding fragment and implications for other B12-dependent enzymes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, USA | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, USA | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, USA | en_US |
dc.identifier.pmid | 7712296 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31943/1/0000896.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0959-440X(94)90275-5 | en_US |
dc.identifier.source | Current Opinion in Structural Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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