1,1-Dimethylhydrazine-induced diuresis

Abstract

Intraperitoneal injections of 80-100 mg/kg of UDMH produced a marked diuresis in rats. Injections of 10 mg per rat resulted in diuresis only when given by the intracerebral route. Although there are significant alterations in the excretory pattern of electrolytes, serum and brain electrolyte levels did not appear to be appreciably altered at the time corresponding to onset of convulsions. Injected ADH is functional in UDMH-treated rats and the action of nicotine tartrate suggests the presence of a functioning neurohypophyseal system. The diuresis can be reversed by appropriate doses of vitamin B6. Hydrazine, monomethylhydrazine, and UDMH produce diuresis in rats. Symmetrical dimethylhydrazine, even at high doses does not; thus a free amino group appears to be necessary for diuretic activity in this series of hydrazines.