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1,1-Dimethylhydrazine-induced diuresis

dc.contributor.authorBarth, Mary L.en_US
dc.contributor.authorGeake, Carol L.en_US
dc.contributor.authorCornish, Herbert H.en_US
dc.date.accessioned2006-04-17T15:35:24Z
dc.date.available2006-04-17T15:35:24Z
dc.date.issued1967-07en_US
dc.identifier.citationBarth, Mary L., Geake, Carol L., Cornish, Herbert H. (1967/07)."1,1-Dimethylhydrazine-induced diuresis." Toxicology and Applied Pharmacology 11(1): 26-34. <http://hdl.handle.net/2027.42/33310>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WXH-4DD32B2-CY/2/08432d25b1c5f61706fa8509378d8240en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/33310
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4293503&dopt=citationen_US
dc.description.abstractIntraperitoneal injections of 80-100 mg/kg of UDMH produced a marked diuresis in rats. Injections of 10 mg per rat resulted in diuresis only when given by the intracerebral route. Although there are significant alterations in the excretory pattern of electrolytes, serum and brain electrolyte levels did not appear to be appreciably altered at the time corresponding to onset of convulsions. Injected ADH is functional in UDMH-treated rats and the action of nicotine tartrate suggests the presence of a functioning neurohypophyseal system. The diuresis can be reversed by appropriate doses of vitamin B6. Hydrazine, monomethylhydrazine, and UDMH produce diuresis in rats. Symmetrical dimethylhydrazine, even at high doses does not; thus a free amino group appears to be necessary for diuretic activity in this series of hydrazines.en_US
dc.format.extent523559 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.title1,1-Dimethylhydrazine-induced diuresisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumInstitute of Industrial Health, University of Michigan, Ann Arbor, Michigan 48104, USA; Department of Industrial Health, School of Public Health University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationumInstitute of Industrial Health, University of Michigan, Ann Arbor, Michigan 48104, USA; Department of Industrial Health, School of Public Health University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationumInstitute of Industrial Health, University of Michigan, Ann Arbor, Michigan 48104, USA; Department of Industrial Health, School of Public Health University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.identifier.pmid4293503en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/33310/1/0000704.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0041-008X(67)90024-5en_US
dc.identifier.sourceToxicology and Applied Pharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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