Poly(Α-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology
dc.contributor.author | Zhang, Ruiyun | en_US |
dc.contributor.author | Ma, Peter X. | en_US |
dc.date.accessioned | 2006-04-19T13:33:11Z | |
dc.date.available | 2006-04-19T13:33:11Z | |
dc.date.issued | 1999-03-15 | en_US |
dc.identifier.citation | Zhang, Ruiyun; Ma, Peter X. (1999)."Poly(Α-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology." Journal of Biomedical Materials Research 44(4): 446-455. <http://hdl.handle.net/2027.42/34413> | en_US |
dc.identifier.issn | 0021-9304 | en_US |
dc.identifier.issn | 1097-4636 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34413 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10397949&dopt=citation | en_US |
dc.description.abstract | Tissue engineering has shown great promise for creating biological alternatives for implants. In this approach, scaffolding plays a pivotal role. Hydroxyapatite mimics the natural bone mineral and has shown good bone-bonding properties. This paper describes the preparation and morphologies of three-dimensional porous composites from poly( L -lactic acid) (PLLA) or poly( D,L -lactic acid-co-glycolic acid) (PLGA) solution and hydroxyapatite (HAP). A thermally induced phase separation technique was used to create the highly porous composite scaffolds for bone-tissue engineering. Freeze drying of the phase-separated polymer/HAP/solvent mixtures produced hard and tough foams with a co-continuous structure of interconnected pores and a polymer/HAP composite skeleton. The microstructure of the pores and the walls was controlled by varying the polymer concentration, HAP content, quenching temperature, polymer, and solvent utilized. The porosity increased with decreasing polymer concentration and HAP content. Foams with porosity as high as 95% were achieved. Pore sizes ranging from several microns to a few hundred microns were obtained. The composite foams showed a significant improvement in mechanical properties over pure polymer foams. They are promising scaffolds for bone-tissue engineering. © 1999 John Wiley & Sons, Inc. J Biomed Mater Res, 44, 446–455, 1999. | en_US |
dc.format.extent | 1074563 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Poly(Α-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, Michigan 48109-1078 | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, Michigan 48109-1078 ; Macromolecular Science and Engineering Center, The University of Michigan, Ann Arbor, Michigan 48109-1078 ; Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 48109–1078 ; Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, Michigan 48109-1078 | en_US |
dc.identifier.pmid | 10397949 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34413/1/11_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1097-4636(19990315)44:4<446::AID-JBM11>3.0.CO;2-F | en_US |
dc.identifier.source | Journal of Biomedical Materials Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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