Surface-modified poly(lactide- co -glycolide) nanospheres for targeted bone imaging with enhanced labeling and delivery of radioisotope
dc.contributor.author | Park, Yoon Jeong | en_US |
dc.contributor.author | Nah, Sook Hee | en_US |
dc.contributor.author | Lee, Jue-Yeon | en_US |
dc.contributor.author | Jeong, Jae Min | en_US |
dc.contributor.author | Chung, Jun Key | en_US |
dc.contributor.author | Lee, Myung Chul | en_US |
dc.contributor.author | Yang, Victor C. | en_US |
dc.contributor.author | Lee, Seung Jin | en_US |
dc.date.accessioned | 2006-04-19T13:34:03Z | |
dc.date.available | 2006-04-19T13:34:03Z | |
dc.date.issued | 2003-12-01 | en_US |
dc.identifier.citation | Park, Yoon Jeong; Nah, Sook Hee; Lee, Jue Yeon; Jeong, Jae Min; Chung, Jun Key; Lee, Myung Chul; Yang, Victor C.; Lee, Seung Jin (2003)."Surface-modified poly(lactide- co -glycolide) nanospheres for targeted bone imaging with enhanced labeling and delivery of radioisotope." Journal of Biomedical Materials Research 67A(3): 751-760. <http://hdl.handle.net/2027.42/34431> | en_US |
dc.identifier.issn | 0021-9304 | en_US |
dc.identifier.issn | 1097-4636 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34431 | |
dc.description.abstract | Surface-modified nanospheres can be utilized for targeting drugs and diagnostic agents to the bone and bone marrow while extending their circulation time in the blood stream. The surface modification of poly(lactide- co -glycolide) (PLGA) nanospheres by radioisotope carrying poly(ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) triblock copolymers (Poloxamer 407) has been assessed by in vitro characterization and in vivo biodistribution studies after intravenous administration of the nanospheres to the mouse. A hydroxyphenylpropionic acid, a ligand for 125 I and 131 I labeling, was conjugated to the hydroxyl group of the Poloxamer 407 by using dicyclohexyl carbodiimide. The ligand-conjugated Poloxamer 407 was adsorbed onto the surface of PLGA nanospheres. Surface coating was confirmed by measuring both size distribution and the surface charge of the nanospheres. Besides, 125 I-labeling efficiency, radiolabeling stability, whole body imaging, and biodistribution of the radioisotope-labeled nanospheres were examined. Ligand-labeled, surface-modified PLGA nanospheres were in 100-nm size ranges, which may be adequate for long-circulation and further bone imaging. 125 I-labeling efficiency was >90% and was more stable at human serum for 24 h. A noticeable decrease in liver or spleen uptake was obtained by the surface-modified nanospheres. 125 I-labeled nanospheres showed higher blood maintenance and bone uptake compared with stannous colloid with the same size distribution. Therefore, a fully biodegradable, radioisotope-carrying, surface-modified nanosphere system has been developed as a promising tool for targeting bone and bone marrows. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 67A: 751–760, 2003 | en_US |
dc.format.extent | 280628 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Surface-modified poly(lactide- co -glycolide) nanospheres for targeted bone imaging with enhanced labeling and delivery of radioisotope | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065 | en_US |
dc.contributor.affiliationother | Department of Industrial Pharmacy, College of Pharmacy, Ewha Womans University, 11-1 Daehyun-Dong, Seodaemun-Ku, Seoul 120-750, Korea | en_US |
dc.contributor.affiliationother | Department of Industrial Pharmacy, College of Pharmacy, Ewha Womans University, 11-1 Daehyun-Dong, Seodaemun-Ku, Seoul 120-750, Korea | en_US |
dc.contributor.affiliationother | Department of Nuclear Medicine, College of Medicine, Seoul National University, 28-2 Yongon-Dong, Chongno-Ku, Seoul 110-820, Korea | en_US |
dc.contributor.affiliationother | Department of Nuclear Medicine, College of Medicine, Seoul National University, 28-2 Yongon-Dong, Chongno-Ku, Seoul 110-820, Korea | en_US |
dc.contributor.affiliationother | Department of Nuclear Medicine, College of Medicine, Seoul National University, 28-2 Yongon-Dong, Chongno-Ku, Seoul 110-820, Korea | en_US |
dc.contributor.affiliationother | Department of Industrial Pharmacy, College of Pharmacy, Ewha Womans University, 11-1 Daehyun-Dong, Seodaemun-Ku, Seoul 120-750, Korea ; Department of Industrial Pharmacy, College of Pharmacy, Ewha Womans University, 11-1 Daehyun-Dong, Seodaemun-Ku, Seoul 120-750, Korea | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34431/1/10167_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jbm.a.10147 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.