Injectable microparticle–gel system for prolonged and localized lidocaine release. II. in vivo anesthetic effects
dc.contributor.author | Chen, Pen-Chung | en_US |
dc.contributor.author | Kohane, Daniel S. | en_US |
dc.contributor.author | Park, Yoon Jeong | en_US |
dc.contributor.author | Bartlett, Robert H. | en_US |
dc.contributor.author | Langer, Robert S. | en_US |
dc.contributor.author | Yang, Victor C. | en_US |
dc.date.accessioned | 2006-04-19T13:34:14Z | |
dc.date.available | 2006-04-19T13:34:14Z | |
dc.date.issued | 2004-09-01 | en_US |
dc.identifier.citation | Chen, Pen-Chung; Kohane, Daniel S.; Park, Yoon Jeong; Bartlett, Robert H.; Langer, Robert; Yang, Victor C. (2004)."Injectable microparticle–gel system for prolonged and localized lidocaine release. II. in vivo anesthetic effects." Journal of Biomedical Materials Research 70A(3): 459-466. <http://hdl.handle.net/2027.42/34435> | en_US |
dc.identifier.issn | 0021-9304 | en_US |
dc.identifier.issn | 1097-4636 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34435 | |
dc.description.abstract | Current treatment protocols for postoperative pain are beset by either the short duration of the anesthetic effect or requirement of hospitalization of the patients. We reported herein a novel treatment by applying to the surgical site a biodegradable microparticle–gel system for prolonged and localized release of encapsulated anesthetic drugs. In a previous publication, lidocaine-loaded poly( D , L -lactic acid) microspheres were fabricated and their formulations were optimized. In vitro characterization of these lidocaine-loaded microspheres, however, revealed a shortcoming of this system; that is, microspheres tend to fuse physically. Fusion of the microspheres could hinder their clinical applications, as it would clog the needle. In this article, we demonstrated that fabricating microspheres with high molecular weight (∼60 KDa) poly(lactic- co -glycolic acid) would increase the glass transition temperature of the microspheres after lidocaine loading, thereby increasing their mechanical stability and eliminating their fusion during storage. Such microspheres containing 31% (w/w) lidocaine in the presence or absence of 25% (w/v) poloxamer 407 gel were then evaluated in vivo by monitoring the sensory and motor functions of the rats after sciatic nerve block, using the previously established hot-plate and weight-bearing testing methods. Results showed that microspheres formulated with poloxamer 407 gel yielded the longest duration of sensory and motor block for a period of approximately 8.5 h, compared to 5 h by microspheres in saline, 5 h by lidocaine in poloxamer 407 gel, and 2 h by lidocaine in saline. This study suggests that the microsphere–gel system containing lidocaine could potentially be applied clinically to the treatment of postoperative pain. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 70A: 459–466, 2004 | en_US |
dc.format.extent | 386784 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Injectable microparticle–gel system for prolonged and localized lidocaine release. II. in vivo anesthetic effects | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065 | en_US |
dc.contributor.affiliationum | School of Medicine, The University of Michigan, Ann Arbor, Michigan 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065 ; College of Pharmacy, The University of Michigan, 428 church Street, Ann Arbor, Michigan 48109-1065 | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston Massachusetts 02114 ; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts | en_US |
dc.contributor.affiliationother | College of Dentistry, Seoul National University, 28-2 Yongon-Dong, Chongno-ku, Seoul 110-749, Korea | en_US |
dc.contributor.affiliationother | Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34435/1/30101_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jbm.a.30101 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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