Determination of the population pharmacokinetic parameters of sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium by simultaneous data fitting using NONMEM
dc.contributor.author | Idkaidek, Nasir M. | en_US |
dc.contributor.author | Amidon, Gordon L. | en_US |
dc.contributor.author | Smith, David E. | en_US |
dc.contributor.author | Najib, Naji M. | en_US |
dc.contributor.author | Hassan, Mazen M. | en_US |
dc.date.accessioned | 2006-04-19T13:41:49Z | |
dc.date.available | 2006-04-19T13:41:49Z | |
dc.date.issued | 1998-04 | en_US |
dc.identifier.citation | Idkaidek, Nasir M.; Amidon, Gordon L.; Smith, David E.; Najib, Naji M.; Hassan, Mazen M. (1998)."Determination of the population pharmacokinetic parameters of sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium by simultaneous data fitting using NONMEM." Biopharmaceutics & Drug Disposition 19(3): 169-174. <http://hdl.handle.net/2027.42/34601> | en_US |
dc.identifier.issn | 0142-2782 | en_US |
dc.identifier.issn | 1099-081X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34601 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9570000&dopt=citation | en_US |
dc.description.abstract | Data from sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium are fitted simultaneously using NONMEM® and the general linear model, ADVAN 5. Absorption and disposition parameters, serum levels, and absorption profiles were determined. The in vivo absorption profiles were determined using the program TOPFIT®. The in vivo absorption for the sustained-release formulation is slow first order and follows a flip-flop model since disposition rate constants are greater than absorption rate constants. Absorption from the enteric-coated form is essentially complete (≥95%) at about 7.5 h, while it is 95% complete at 24 h from the sustained-release formulation. This suggests likely absorption from the colon in the case of the sustained-release formulation since absorption is only 75% complete during the first 10 h. The sustained-release relative bioavailability is 90–99%. Absorption from the suppository is essentially complete at about 4.5 h. However, the relative bioavailability of the suppository formulation is low (55%), since defecation may remove the drug from the absorption site before complete absorption. © 1998 John Wiley & Sons, Ltd. | en_US |
dc.format.extent | 145646 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry | en_US |
dc.title | Determination of the population pharmacokinetic parameters of sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium by simultaneous data fitting using NONMEM | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109-1065, USA ; College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA. | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109-1065, USA | en_US |
dc.contributor.affiliationother | Department of Pharmaceutics, Faculty of Pharmacy, University of Science and Technology, Irbid, Jordan | en_US |
dc.contributor.affiliationother | Department of Pharmaceutics, Faculty of Pharmacy, University of Science and Technology, Irbid, Jordan | en_US |
dc.contributor.affiliationother | Faculty of Pharmacy and Medical Sciences, Amman University, Amman, Jordan | en_US |
dc.identifier.pmid | 9570000 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34601/1/83_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1099-081X(199804)19:3<169::AID-BDD83>3.0.CO;2-C | en_US |
dc.identifier.source | Biopharmaceutics & Drug Disposition | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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