Decreased striatal monoaminergic terminals in multiple system atrophy detected with positron emission tomography
dc.contributor.author | Gilman, Sid | en_US |
dc.contributor.author | Koeppe, Robert A. | en_US |
dc.contributor.author | Junck, Larry | en_US |
dc.contributor.author | Little, Roderick J. A. | en_US |
dc.contributor.author | Kluin, Karen J. | en_US |
dc.contributor.author | Heumann, Mary | en_US |
dc.contributor.author | Martorello, Susan | en_US |
dc.contributor.author | Johanns, Jewel R. | en_US |
dc.date.accessioned | 2006-04-19T13:56:14Z | |
dc.date.available | 2006-04-19T13:56:14Z | |
dc.date.issued | 1999-06 | en_US |
dc.identifier.citation | Gilman, Sid; Koeppe, Robert A.; Junck, Larry; Little, Roderick; Kluin, Karen J.; Heumann, Mary; Martorello, Susan; Johanns, Jewel (1999)."Decreased striatal monoaminergic terminals in multiple system atrophy detected with positron emission tomography." Annals of Neurology 45(6): 769-777. <http://hdl.handle.net/2027.42/34881> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34881 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10360769&dopt=citation | en_US |
dc.description.abstract | We examined the density of striatal presynaptic monoaminergic terminals, using a ligand for the type 2 vesicular monoamine transporter, (+)-[ 11 C]dihydrotetrabenazine, with positron emission tomography in 7 normal control subjects, 8 multiple system atrophy (MSA) patients with predominantly parkinsonian features (MSA-P), 8 MSA patients with principally cerebellar dysfunction (MSA-C), and 6 sporadic olivopontocerebellar atrophy (sOPCA) patients. The findings were correlated with the results of neurological evaluations and magnetic resonance imaging studies. Specific binding was significantly reduced in the putamen of all patient groups in the order MSA-P < MSA-C < sOPCA, compared with controls. Mean blood-to-brain ligand transport (K 1 ) was significantly decreased in the putamen of all patient groups and in the cerebellar hemispheres of MSA-C and sOPCA but not MSA-P groups, compared with controls. Significant negative correlations were found between striatal binding and the intensity of parkinsonian features and between cerebellar K 1 and the intensity of cerebellar dysfunction. The results suggest fundamental differences between MSA-P and MSA-C groups reflecting differential severity of degeneration of nigrostriatal and cerebellar systems in these two forms of MSA. The findings also show that some sOPCA patients have subclinical nigrostriatal dysfunction and are at risk of developing MSA with disease progression. Ann Neurol 1999;45:769–777 | en_US |
dc.format.extent | 180928 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Neuroscience | en_US |
dc.title | Decreased striatal monoaminergic terminals in multiple system atrophy detected with positron emission tomography | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI ; Department of Neurology, University of Michigan Medical Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0316 | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI ; Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan, Ann Arbor, MI | en_US |
dc.identifier.pmid | 10360769 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34881/1/11_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/1531-8249(199906)45:6<769::AID-ANA11>3.0.CO;2-G | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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