Glucose transport in brain and retina: implications in the management and complications of diabetes
dc.contributor.author | Kumagai, Arno K. | en_US |
dc.date.accessioned | 2006-04-19T14:18:28Z | |
dc.date.available | 2006-04-19T14:18:28Z | |
dc.date.issued | 1999-07 | en_US |
dc.identifier.citation | Kumagai, Arno K. (1999)."Glucose transport in brain and retina: implications in the management and complications of diabetes." Diabetes/Metabolism Research and Reviews 15(4): 261-273. <http://hdl.handle.net/2027.42/35242> | en_US |
dc.identifier.issn | 1520-7552 | en_US |
dc.identifier.issn | 1520-7560 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/35242 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10495475&dopt=citation | en_US |
dc.description.abstract | Neural tissue is entirely dependent on glucose for normal metabolic activity. Since glucose stores in the brain and retina are negligible compared to glucose demand, metabolism in these tissues is dependent upon adequate glucose delivery from the systemic circulation. In the brain, the critical interface for glucose transport is at the brain capillary endothelial cells which comprise the blood–brain barrier (BBB). In the retina, transport occurs across the retinal capillary endothelial cells of the inner blood–retinal barrier (BRB) and the retinal pigment epithelium of the outer BRB. Because glucose transport across these barriers is mediated exclusively by the sodium-independent glucose transporter GLUT1, changes in endothelial glucose transport and GLUT1 abundance in the barriers of the brain and retina may have profound consequences on glucose delivery to these tissues and major implications in the development of two major diabetic complications, namely insulin-induced hypoglycemia and diabetic retinopathy. This review discusses the regulation of brain and retinal glucose transport and glucose transporter expression and considers the role of changes in glucose transporter expression in the development of two of the most devastating complications of long-standing diabetes mellitus and its management. Copyright © 1999 John Wiley & Sons, Ltd. | en_US |
dc.format.extent | 225445 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Diabetes and Clinical Endocrinology | en_US |
dc.title | Glucose transport in brain and retina: implications in the management and complications of diabetes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Michigan Diabetes Research and Training Center, University of Michigan Medical School, Ann Arbor, MI, USA ; Department of Internal Medicine, 5570 MSRB-2, University of Michigan Medical School, Ann Arbor, MI 48109–0678, USA | en_US |
dc.identifier.pmid | 10495475 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/35242/1/43_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1520-7560(199907/08)15:4<261::AID-DMRR43>3.0.CO;2-Z | en_US |
dc.identifier.source | Diabetes/Metabolism Research and Reviews | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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