Poly- L -lysine amplification of protamine immobilization and heparin adsorption
dc.contributor.author | Zhang, Yuehua | en_US |
dc.contributor.author | Singh, Vijendra K. | en_US |
dc.contributor.author | Yang, Victor C. | en_US |
dc.date.accessioned | 2006-04-28T16:36:15Z | |
dc.date.available | 2006-04-28T16:36:15Z | |
dc.date.issued | 1998-11 | en_US |
dc.identifier.citation | Zhang, Yuehua; Singh, Vijendra K.; Yang, Victor C. (1998)."Poly- L -lysine amplification of protamine immobilization and heparin adsorption." Journal of Biomedical Materials Research 42(2): 182-187. <http://hdl.handle.net/2027.42/38021> | en_US |
dc.identifier.issn | 0021-9304 | en_US |
dc.identifier.issn | 1097-4636 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38021 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9773814&dopt=citation | en_US |
dc.description.abstract | We previously reported the development of a cellulose fiber based blood filter device containing immobilized protamine (termed protamine filter) that could be used to control both heparin- and protamine-induced complications during extracorporeal therapy. To achieve enhanced heparin adsorption on the fibers, we examined the possibility of utilizing the poly- L -lysine based amplification method to augment protamine loading on the fiber, as well as to create multiple layers of immobilized protamine for heparin interaction. Results show that such a method yielded about a threefold increase in protamine loading and, consequently, about a fourfold enhancement in heparin adsorption when compared with the control without poly- L -lysine amplification. This technological improvement may facilitate development of a new generation of protamine filters with capacity and efficacy suitable for various clinical applications in extracorporeal heparin removal. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 42, 182–187, 1998. | en_US |
dc.format.extent | 225973 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Poly- L -lysine amplification of protamine immobilization and heparin adsorption | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065 ; College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065 | en_US |
dc.identifier.pmid | 9773814 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38021/1/3_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1097-4636(199811)42:2<182::AID-JBM3>3.0.CO;2-L | en_US |
dc.identifier.source | Journal of Biomedical Materials Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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